魏本玲徐州矿务集团总医院庞庄医院内一科，江苏徐州　221141

铝碳酸镁在伴糜烂的非萎缩性胃炎中应用探讨

魏本玲
徐州矿务集团总医院庞庄医院内一科，江苏徐州221141

目的观察铝碳酸镁在治疗非萎缩性胃炎伴糜烂中的疗效及对幽门螺杆菌相关胃黏膜损伤的保护作用。方法选取2012年2月～2015年2月我院收治的非萎缩性胃炎伴糜烂患者共344例，按照随机的原则将其分为对照组和观察组各172例，其中对照组给予盐酸雷尼替丁胶囊进行治疗，观察组采用铝碳酸镁进行治疗，以2周为一个疗程进行检查评估，比较两组患者在治疗前后的临床症状变化，并进行胃镜、病理组织活检及幽门螺杆菌（Hp）测定了解患者治疗恢复情况。结果两组患者治疗后胃痛、胃胀及暖气等临床症状得到显著改善，其中对照组治愈28例、显效40例、有效59例、无效45例，治疗有效率为73.8%。胃黏膜充血、水肿等损伤恢复率为75.6%，Hp转阴140例（81.4%）；观察组治愈37例、显效43例、有效62例、无效30例，治疗有效率为82.6%，胃黏膜均恢复正常，Hp全部转阴，两组间比较差异具有统计学意义（P＜0.05）。结论研究发现，铝碳酸镁在治疗非萎缩性胃炎伴糜烂中疗效显著，有利于减轻幽门螺杆菌相关胃黏膜损伤并根除Hp，值得在临床上进行推广和应用。

慢性萎缩性胃炎：糜烂；盐酸雷尼替丁胶囊；铝碳酸镁；幽门杆菌

［Abstract］Objective To observe the effect of hydrota1cite in treatment of non-atrophic gastritis with erosion and its protective effect on gastric mucosa1 1esion re1ated to he1icobacter py1ori（Hp）.Methods 344 patients with non-atrophic gastritis with erosion treated in our hospita1 from February 2012 to February 2015 were se1ected and random1y divided into contro1 group and observation group，each with 172 cases.Patients in the contro1 group were given ranitidine hydroch1oride capsu1es，whi1e patients in the observation group were given hydrota1cite，both for two weeks and then the effects in both groups were assessed.Changes of c1inica1 symptoms were compared between two groups，recovery statuses of patients were measured by gastroscopy，histopatho1ogica1 biopsy，and Hp detection.Results After treatment，c1inica1 symptoms such as stomachache，stomach distension，and be1ching were significant1y re1ieved in both groups.In the contro1 group，28 patients were cured，40 were significant1y re1ieved，59 were partia11y re1ieved，and 45 were not re-1ieved；the effective rate of treatment was 73.8%；the recovery rate of 1esions such as gastric mucosa1 hyperemia and edema was 75.6%，and HP negative conversion was observed in 140 patients（81.4%）.In the observation group，37 patients were cured，43 were significant1y re1ieved，62 were partia11y re1ieved，and 30 were not re1ieved；the effective rate of treatment was 82.6%；the 1esions of gastric mucosa were a11 cured and HP negative conversion was observed in a11 patients.The differences between two groups were statistica11y significant（P＜0.05）.Conclusion Hydrota1cite has significant effect in treatment of non-atrophic gastritis with erosion，and it can contribute to remission of gastric mucosa1 1esion re1ated to he1icobacter py1ori and eradication of Hp，thus is worthy to be promoted in c1inica1 practice.

［Key words］Chronic atrophic gastritis；Erosion；Ranitidine hydroch1oride capsu1e；Hydrota1cite；He1icobacter py1ori

非萎缩性（浅表性）胃炎是受多重因素影响而引起的胃黏膜慢性炎症反应，患者发病后胃黏膜层的淋巴细胞和浆细胞出现浸润性改变，但未出现腺体的减少或萎缩。……