陈 洁，彭秀军，石 芊，王 静，隋艳来

康柏西普联合曲安奈德玻璃体内注射治疗黄斑水肿疗效

陈 洁，彭秀军，石 芊，王 静，隋艳来

目的 研究康柏西普联合曲安奈德玻璃体内注射治疗黄斑水肿疗效。方法 经光学相干断层扫描和眼底血管荧光造影检查确诊糖尿病黄斑水肿患者45例，共85只眼，对照组采用单纯曲安奈德玻璃体内注射治疗，治疗组采用康柏西普联合曲安奈德治疗，分别对治疗前和治疗后1、3个月患者光学相干断层扫描、矫正视力和眼压等进行观察，用SPASS 17.0软件进行统计学分析。结果 2种方法治疗3个月，患者视力都有所提高，且2种药物联合使用对光学相干断层扫描和矫正视力的改善效果更为显著。结论 康柏西普联合曲安奈德玻璃体内注射是治疗糖尿病黄斑水肿的有效方法，可以提高治疗的安全性和有效性。

康柏西普；曲安奈德；光学相干断层扫描；矫正视力

［Abstract］Objective This study is to explore the curative effect of conbercept combined with triamcinolone acetonide to treat retinal veinobstruction caused by macular edema.Methods We used optical coherence tomography（OCT）and fundus fluorescein angiography（FFA）to diagnose 45 patients with diabetic macular edema，a total of 85 eyes included.Patients in A groups were simply treated with triamcinolone acetonide treatment，while in B groups were treated by conbercept combined with triamcinolone acetonide.OCT and corrected visual acuity，intraocular pressure and other adverse reactions were observed before and after treatment for 1 months and 3 months respectively.The statistical analysis was performed with SPSS 17.0.Results Compared with pretherapy，the patient’s visual acuity had largely improved for 3 months after treatment.OCT and corrected visual acuity improvement effect were more significant in group of drugs combination.Conclusion Conbercept combined with intravitreal injection of triamcinolone acetonide is an effective method for diabetic macular edema of therapy，which can improve the safety and efficacy of treatment.

［Key words］Conbercept；Triamcinolone acetonide；Optical coherence tomography（OCT）；Visual acuity

糖尿病黄斑水肿（diabetic macular edema，DME）是由糖尿病视网膜病变引起的［1］，严重影响糖尿病患者的视力［2］。随着科学技术的发展，对其治疗手段也在不断更新，传统方法包括激光治疗和玻璃体手术。近年来，单独用药疗效的局限性，联合用药或用药配合激光技术已经成为治疗黄斑水肿的主要手段［3-4］。其中，康柏西普和曲安奈德是临床较常用的2种药物，2种都能抑制新生血管的生长。前者主要参与阻断血管内皮生长因子介导的信号传递，是一种IgG-Fc片段融合蛋白［5］，因其疗效不明显、价格昂贵，未被广泛推广［6］。……