23例奥美拉唑治疗胃溃疡合并出血的临床疗效分析

2016-08-30刘东旭

中国卫生标准管理 2016年13期

杨洋刘东旭毛晶

杨洋刘东旭毛晶

目的探讨奥美拉唑治疗胃溃疡合并出血的临床治疗方法及效果。方法将2013年2月～2014年12月，我院收录的胃溃疡合并出血的患者46例，随机分为对照组和观察组，观察组采用奥美拉唑治疗，对照组采用泮托拉唑治疗，比较两组的治疗效果和不良反应。结果观察组的临床总有效率与对照组比较，差异无统计学意义（P＞0.05）。观察组和对照组的不良反应相比，差异不具有统计学意义（P＞0.05）。观察组的胃出血复发情况少于对照组，两者相比差异有统计学意义（P＜0.05）。结论奥美拉唑与泮托拉唑用于治疗胃溃疡合并出血的疗效相当，不良反应差异不具有统计学意义，泮托拉唑具有较短的止血时间，奥美拉唑的复发率低于泮托拉唑。

奥美拉唑；胃溃疡合并出血；临床观察；泮托拉唑

doi：10.3969/j.issn.1674-9316.2016.13.061

【Abstract】

Objective To investigate the treatment of gastric ulcer with hemorrhage in omeprazole treatment and clinical effect. Methods From February 2013 to December 2014，our hospital included merger ulcer bleeding 46 patients were randomly divided into control group and observation group，the observation group for oral omeprazole treatment，the control group with oral pantoprazole treatment，therapeutic effects and adverse reactions were compared. Results The observation group and control group of total efficiency compared without significant difference（P＞0.05）. Adverse reactions of observation group and the control group compared to having no significant difference（P＞0.05）. Bleeding recurrence of observation group was significantly less than the control group，and there was statistical difference（P＜0.05）.Conclusion Omeprazole and Pantoprazole have similar effect in the treatment of gastric ulcer bleeding with no significant adverse reaction，Pantoprazole has hemostatic time shorter，but omeprazole can shorten recurrence rate.

【Key words】Omeprazole，Gastric ulcer and hemorrhage，Clinical observation，Pantoprazole

胃溃疡发病原因是胃酸和胃蛋白酶对黏膜产生自身消化［1］，胃溃疡属于慢性、难治愈、复发性高的疾病，患者常常表现腹胀、上腹疼痛、恶心以及泛酸［2］等，严重时会导致胃出血、幽门梗阻、穿孔和癌变等，严重威胁患者的生命安全［3］。本研究中，选取我院46例胃溃疡合并出血的患者为研究对象，比较奥美拉唑和泮托拉唑治疗胃溃疡合并出血的临床效果，现报道如下。