张勇大连市普兰店区中心医院心内科，辽宁大连　116200

氯沙坦钾氢氯噻嗪片治疗原发性高血压的疗效观察

张勇
大连市普兰店区中心医院心内科，辽宁大连116200

目的 观察氯沙坦钾氢氯噻嗪片治疗原发性高血压的临床效果。方法 选取2012年3月～2014年9月在我院就诊的原发性高血压患者98例的临床资料进行回顾性分析，50例患者采用氯沙坦钾氢氯噻嗪片治疗为研究组，48例患者采用氢氯噻嗪片治疗为对照组，比较两组的血压变化及临床疗效。结果 治疗后6周末两组收缩压及舒张压均显著低于治疗前，差异有高度统计学意义（P＜0.01）；研究组治疗后6周末收缩压及舒张压均显著低于对照组，差异有高度统计学意义（P＜0.01）。研究组总有效率显著高于对照组，差异有统计学意义（P＜0.05）。结论 氯沙坦钾氢氯噻嗪片治疗原发性高血压安全有效，不良反应小且患者依从性好。

氯沙坦钾氢氯噻嗪片；原发性高血压；血脂；血糖；血尿酸

［Abstract］Objective To observe the clinical efficacy of losartan potassium and hydrochlorothiazide tablets in treatment of essential hypertension.Methods Clinic data of 98 patients with essential hypertension in our hospital from March 2012 to September 2014 were respectively analyzed.50 cases treated with losartan potassium and hydrochlorothiazide tablets were coneated as study group，and 48 cases treated with hydrochlorothiazide were coneated as control group. The lood pressure and clinical efficacy of two groups were compared.Results Six weekend after treatment，SBP and DBP of two groups were lower than those before treatment（P＜0.01）.And SBP and DBP of study group were lower than control group（P＜0.01）.Total effective rate of study group was higher than control group（P＜0.05）.Conclusion The clinical effect of losartan potassium and hydrochlorothiazide tablets in treatment of essential hypertension is safe and effective，the adverse reactions are low and patient compliance is good.

［Key words］Losartan potassium and hydrochlorothiazide；Essential hypertension；Blood lipid；Blood glucose；Serum uric acid

原发性高血压患病率呈逐年上升趋势，根据2002年全国调查报告显示我国成年人群高血压的患病率高达18.8%，全国高血压患者约1.6亿，比1991年增加7000多万［1］。原发性高血压可导致多种心脑血管并发症，影响心脑肾等重要脏器的结构及功能，导致器官衰竭，危及患者生命。目前高血压仍然无有效的治愈方法，临床上主要通过口服降压药物控制血压在合理水平。氯沙坦钾氢氯噻嗪片是血管紧张素II受体拮抗剂和利尿剂的复方制剂。我们采用氯沙坦钾氢氯噻嗪片治疗原发性高血压，取得了较好的临床效果，现报道如下。……