赵静开封市中医院制剂室，河南开封　475000

普通肝素联合低分子肝素钙改善症状轻微急性缺血性脑卒中患者神经功能的效果分析

赵静
开封市中医院制剂室，河南开封475000

目的分析普通肝素联合低分子肝素钙改善症状轻微急性缺血性脑卒中患者神经功能的效果。方法采用随机数字表法将开封市中医院脑病科2012年9月—2015年9月期间收治的95例症状轻微急性缺血性脑卒中患者进行分组，单药组给予普通肝素联合神经内科基础治疗，联合组增加低分子肝素钙治疗，采用神经功能缺损评分（NIHSS评分）评价患者治疗前后神经功能改善效果。 结果两组治疗方案均能够降低治疗后NIHSS评分，但联合组降低治疗后NIHSS评分幅度明显高于单药组，P＜0.05；联合组总有效率84.48%高于单药组68.42%，P＜0.05；两组均未发生药物不良反应。结论普通肝素联合低分子肝素钙改善症状轻微急性缺血性脑卒中患者神经功能效果确切，能够结合普通肝素快速抗凝和低分子肝素维持持续抗凝等特点改善预后。

普通肝素；低分子肝素钙；急性缺血性脑卒中；神经功能缺损评分

［Abstract］Objective To analyze the unfractionated heparin and low molecular heparin improve mild symptoms of acute ischemic stroke patients with neurological effects.Methods A random number table encephalopathy Kaifeng City Hospital from September 2012 to September 2015 during the 95 cases with mild symptoms in patients with acute ischemic stroke group，monotherapy group received unfractionated heparin neurology basic treatment，Joint Group to increase low molecular weight heparin therapy，the use of neurological deficit score（NIHSS score）neurological evaluation before and after the effect of improving patient treatment.Results Two treatment programs are able to reduce posttreatment NIHSS score，but the combined group after treatment NIHSS score lower rate significantly higher than single drug group，P＜0.05；combined group total efficiency 84.48%higher than the monotherapy group 68.42%，P＜0.05；two groups were adverse drug reactions.Conclusion unfractionated heparin and low molecular heparin improve mild symptoms of acute ischemic stroke patients neurological exact effect，capable of binding heparin and low molecular weight heparin anticoagulation maintain rapid continuous anticoagulation and so improve the prognosis.

［Key words］Unfractionated heparin；LMWH；Acute ischemic stroke；Neurological function

症状轻微的缺血性脑卒中是临床常见的一种急性神经内科疾病，多数学者因医疗环境复杂而不推荐使用抗凝剂［1］，而常规非溶栓或抗凝治疗方案效果欠佳［2］。笔者以开封市中医院脑病科2012年9月—2015 年9月期间收治的95例症状轻微急性缺血性脑卒中患者作为研究对象，采用普通肝素联合低分子肝素钙改善48例症状轻微急性缺血性脑卒中患者神经功能效果确切，现报道如下。……