凌征梅（广东省梅州市中医医院　梅州　514000）

Abstract：Objective：To probe into the effectiveness and safety of fluoxetine combined with olanzapine in the treatment of depression. Methods：90 patients with depression and who accepted treatments in our hospital from June，2014 to June，2015 were selected，and were divided into the observation group of 45 cases and the control group of 45 cases by the two color random grouping method.In the control group，they were treated with fluoxetine while in the observation group，they were treated with the fluoxetine combined with olanzapine.Then，the clinical treatment effects of two groups of patients were observed Outcome：The total effective rate in the observation group was 75.55%，which was higher than that in the control group of 46.67%；And the incidence rate of adverse reactions in the observation group was 20%，which lower than that in the control group of 37.78%（P＜0.05）；There was no significant difference in the HAMD score between the two groups before treatment.After treatment，the HAMD score of the patients in the observation group was significantly lower than that in the control group（P＜0.05）.Conclusion：For the patients with depression，the treatment of fluoxetine combined with olanzapine which it is beneficial to alleviate clinical symptoms，improve the treatment effect，and the adverse reaction is little，safety is high，thus it is worth to be widely applied and promoted in clinical.Key words：Depression Olanzapine Fluoxetine Adverse reaction

氟西汀合并奥氮平治疗抑郁症的临床疗效和安全性分析

凌征梅（广东省梅州市中医医院梅州514000）

目的：观察分析氟西汀合并奥氮平治疗抑郁症的有效性和安全性。方法：选取我院2014年6月～2015年6月收治的90例抑郁症患者，运用双色球随机分组法分为观察组45例和对照组45例，对照组采用氟西汀治疗，观察组采用氟西汀合并奥氮平治疗，观察两组临床治疗效果。结果：观察组治疗总有效率75.55%，高于对照组的46.67%；观察组不良反应发生率20.00%，低于对照组的37.78%（P＜0.05）；治疗前两组HAMD评分无明显差异，治疗后观察组HAMD评分较对照组显著降低（P＜0.05）。结论：针对抑郁症，采用氟西汀合并奥氮平治疗，有利于缓解临床症状，提高治疗效果，不良反应少，安全性高，值得临床推广。

抑郁症 奥氮平 氟西汀 不良反应

Abstract：Objective：To probe into the effectiveness and safety of fluoxetine combined with olanzapine in the treatment of depression. Methods：90 patients with depression and who accepted treatments in our hospital from June，2014 to June，2015 were selected，and were divided into the observation group of 45 cases and the control group of 45 cases by the two color random grouping method.In the control group，they were treated with fluoxetine while in the observation group，they were treated with the fluoxetine combined with olanzapine.Then，the clinical treatment effects of two groups of patients were observed Outcome：The total effective rate in the observation group was 75.55%，which was higher than that in the control group of 46.67%；And the incidence rate of adverse reactions in the observation group was 20%，which lower than that in the control group of 37.78%（P＜0.05）；There was no significant difference in the HAMD score between the two groups before treatment.After treatment，the HAMD score of the patients in the observation group was significantly lower than that in the control group（P＜0.05）.Conclusion：For the patients with depression，the treatment of fluoxetine combined with olanzapine which it is beneficial to alleviate clinical symptoms，improve the treatment effect，and the adverse reaction is little，safety is high，thus it is worth to be widely applied and promoted in clinical.
Key words：Depression Olanzapine Fluoxetine Adverse reaction

近年来，我国社会经济飞速发展，人们生活、工作压力不断提高，抑郁症作为精神科临床常见病，发病率呈逐年上升趋势，需引起临床高度重视。抑郁症发病原因和机制十分复杂，可能与心理、生理、社会环境有关［1］，临床表现为情绪低落、思维迟缓、意志活动减退、认知功能损害、睡眠障碍、食欲降低、乏力等，严重者可出现自杀行为，给患者生活、工作带来严重影响。临床治疗抑郁症以药物为主，尽管精神药理学科飞速发展，抑郁症相关药物不断研发，新型药物层出不穷，但仍有部分患者无法取得良好的治疗效果。氟西汀、奥氮平是治疗抑郁症常见药物。本文收集了90例抑郁症患者临床资料，探讨氟西汀联合奥氮平的治疗安全性和有效性，报道如下。……