刘化文



氢吗啡酮与舒芬太尼在骨科手术后自控静脉镇痛中的应用比较

刘化文

【摘要】目的 对比分析氢吗啡酮与舒芬太尼在骨科手术后自控静脉镇痛中的应用效果。方法 回顾性分析在我院接受骨科手术的70例患者临床资料，随机分为2组，均35例。对照组接受舒芬太尼进行镇痛，观察组接受氢吗啡酮进行镇痛。对比分析两组的镇痛效果。结果 两组的Ramesay评分相比，对照组低于观察组，差异有统计学意义（P＜0．05）；对照组的VAS评分及不良反应总发生率高于观察组，差异有统计学意义（P＜0．05）。结论 氢吗啡酮应用于骨科手术后自控静脉镇痛中效果优于舒芬太尼，可有效减轻患者疼痛。

【关键词】氢吗啡酮；舒芬太尼；骨科手术；自控静脉镇痛

Objective To compare the application effect of hydromorphone and sufentanil in patient-controlled intravenous analgesia after surgery in the orthopedic operation． Methods The clinical data of 70 patients in our hospital were randomly divided into 2 groups， and 35 cases were randomly divided into groups． The control group were treated with sufentanil analgesia， observation group were received hydromorphone analgesia． The analgesic effects of the two groups were compared and analyzed． Results Comparing with the control group，the Ramesay scores of the two groups were significantly lower than those in the control group（P＜0．05）． The VAS score and adverse reaction rate of the control group were higher than that of the observation group，the difference was significant（P＜0．05）． Conclusion Hydromorphone used in patient-controlled intravenous analgesia after orthopedic surgery is better than that of sufentanil， can effectively reduce the pain of patients．

【Key words】Hydromorphone，Sufentanil，Orthopedic operation，Patient-controlled intravenous analgesia

氢吗啡酮是神经系统用药，是一种吗啡衍生物［1］。氢吗啡酮已被广泛应用到手术患者的术后静脉镇痛中［2］。但临床对氢吗啡酮的镇痛效果及不良反应发生情况的研究较少［3］。本研究对70例接受骨科手术的患者分组使用氢吗啡酮与舒芬太尼进行术后镇痛，对比镇痛效果。报道如下。

1 资料与方法

1.1 一般资料

回顾性分析2014年2月～2015年1月在我院接受骨科手术的70例患者的临床资料，随机分为2组，均35例。其中对照组男21例，女14例；年龄20～62岁，平均（43.6±2.3）岁。观察组男22例，女13例；年龄21～63岁，平均（44.6±2.6）岁。两组的性别、年龄等一般资料相比，差异无统计学意义（P＞0.05），具有可比性。

1.2 方法

患者进入手术室后均对静脉进行常规开放，实施腰-硬联合麻醉。对照组使用100μg的舒芬太尼（宜昌人福药业有限责任公司，国药准字H20054172）和5 mg的托烷司琼（山西普德药业股份有限公司，国药准字H20080616）；……