傅荣

[摘要] 目的 讨论采用化学发光法检测3型糖尿病患者胰岛素与血清C肽水平。 方法 选取150例2型糖尿病患者，患者于清晨空腹状态下取坐位，静脉抽取手肘部位血液5 mL，用化学发光法检测其血清中胰岛素和C肽的含量，设置同样150例健康人作为对照，都经电解质、血脂、血压、血糖、心肌酶、肝肾功能等检查无异常，且家族无糖尿病病史。两组在年龄、性别、病情等方面均差异无统计学意义，具有可比性（P>0.05）。 结果 对照组患者的胰岛素和C肽含量为（16.25±4.02）U/L、（1.42±0.08）ng/L，观察组患者分别为（10.34±3.19）U/L、（1.03±0.10）ng/L，观察组患者胰岛素和C肽水平都明显低于对照组，差异有统计学意义。 结论 采用化学发光法检测2型糖尿病患者胰岛素与血清C肽水平操作简便，重复性好，无污染，患者依从性也高，在临床上值得应用推广。[关键词] 2型糖尿病；胰岛素；C肽；化学发光法；价值分析[中图分类号] R587.1

[文献标识码] A

[文章编号] 1672-4062（2016）03（a）-0074-02Analysis of the Value of Insulin and Serum C Peptide Level in Patients with Type 2 Diabetes by ChemiluminescenceFU RongHubei Provincial Hospital of Traditional Chinese and Western Medicine（Hubei Xinhua Hospital）， Wuhan，Hubei Province， 430015 China[Abstract] Objective To investigate the detection of insulin and serum C peptide levels in patients with type. Methods 150 cases of patients with type 2 diabetes， patients in the fasting state take seat， vein extraction elbow blood 5ml， chemical luminescence method testing the serum insulin and C-peptide levels， set the same 150 cases of healthy people as control， the electrolyte， blood lipids， blood pressure， blood glucose， myocardial enzymes， liver and kidney function examination no abnormalities and family had a history of diabetes. There were no significant differences in age， sex， disease and other aspects between the two groups， which were comparable （P>0.05）. Results In the control group， the insulin and C peptide in（16.25±4.02）U/L，（1.42±0.08）ng/L. Patients in the observation group were（10.34±3.19） U/L，（1.03±0.10）ng/L. Observation group， the serum insulin and C-peptide levels were significantly lower than those of the control group， with significant difference. Conclusion This paper discusses the method of using chemiluminescence to detect insulin and serum C peptide level in patients with type 2 diabetes mellitus is simple， good repeatability， no pollution， patient compliance is high， and it is worthy of application in clinical practice.[Key words] 2 type Key diabetes mellitus； Insulin； C peptide； Chemiluminescence； Value analysis糖尿病是一种由于胰岛素分泌缺陷或生物功能受损引起的表现为高血糖的代谢性疾病，血糖长期处于高水平会导致各组织器官，特别是肾、心脏、血管、神经系统的功能性损伤。糖尿病的临床突出表现为“三多一少”，即多饮多尿多食、消瘦，多见于1型糖尿病，而2型糖尿病则表现为肥胖，乏力，不及时治疗才会发生体重下降等特征。糖尿病分为两种类型，1型和2型，前者患者多小于30岁，发病突然，血糖水平高，并伴有上述的“三多一少”症状，口服降糖药无效，需用胰岛素治疗；后者多见于中老年人，肥胖患者发病率较高，常伴有高血压、高血脂、动脉粥样硬化等疾病，发病不明显，早期血清胰岛素水平早期不定，晚期较低，且C肽水平也明显降低，该研究即通过检测2型糖尿病患者胰岛素与血清C肽水平来进行分析患者病情。糖尿……