郭兆娟 翟华强 袁一平 张田 李睿 孔李婷 贾晓玉

[摘要]通过整理《本草纲目》对熟地黄炮制历史源流、炮制方法及临床应用等方面的记载，对比分析国医大师金世元教授理论认识及相关实践操作，以继承和发展熟地黄临床调剂技术。在分析过程中，以“熟地黄”、“炮制方法”、“临床应用”、“李时珍”、“金世元”、“调剂技术”为关键词，在中国知网进行文献检索；系统梳理《神农本草经》、《本草图经》、《本草纲目》、《景岳全书》相关古籍，归纳熟地黄炮制及功效的历史沿革；金世元教授注重熟地黄的临床调剂技术，包括熟地黄性状辨别技术、临床炮制技术、处方审核技术、处方应付技术、发药交代技术、临床煎煮技术、采购管理技术和贮存养护供应技术。通过整理考证得知，《本草纲目》对熟地黄炮制的历史源流、炮制方法及临床应用等方面进行了详细的记载；熟地黄蒸制方法始载于《金匮要略》，李时珍非常注重熟地黄“九蒸九晾”的炮制方法，并在临床应用方面将其与生地黄、鲜地黄区分开来。金世元教授发展完善了熟地黄的臨床调剂技术，以其自身“精药通医”的知识结构传承李时珍药学学术思想，为熟地黄的临床应用提供科学的药学服务。

[关键词]李时珍；熟地黄；金世元；调剂技术；药学服务

[Abstract]To collect the historical origin， processing methods and clinical application of Rehmanniae Radix Preparata in Compendium of Materia Medica， compare and analyze the theoretical knowledge and relevant practical operation of national physician master Jin Shiyuan， which is beneficial for the inheritance and development of Rehmanniae Radix Preparata′s clinical dispensing technology In the analysis process， CNKI was searched with "Rehmanniae Radix Preparata"， "Processing method"， "Clinical application" "Li Shizhen"， "Jin Shiyuan"， and "Dispensing technology" as keywords In addition， Shennong′s Herbal Classic， Bencao Tujing （illustrated Classics of Materia Medica）， Compendium of Materia Medica， Jingyue Quanshu （Jingyue′s Complete Works） and related ancient books were accessed systematically to summarize the historical change of processing methods and efficacy of Rehmanniae Radix Praeparata Professor Jin Shiyuan emphasizes the clinical dispensing technology of Rehmanniae Radix Praeparata， including its nature identification technology， clinical processing technology， prescription audit technology， prescription coping technology， drug delivery technology， clinical decocting technology， purchasing management technology as well as storage， maintenance and supply technology Through the collation and research， it was confirmed that historical origin， processing methods and clinical application of Rehmanniae Radix Preparata were recorded in details in Compendium of Materia Medica Steaming method of Rehmanniae Radix Preparata was originated from Synopsis of Golden Chamber Li Shizhen attached great importance to the processing method of "steaming and drying alternatively for nine times" for Rehmanniae Radix Preparata， and differentiated it from Radix Rehmanniae Recen and fresh rehmannia root in clinical applications Professor Jin Shiyuan has developed and improved the clinical dispensing technology of Rehmanniae Radix Praeparata， and carried forward the essence of Li Shizhen′s pharmaceutical academic thought with his own proficient knowledge structure in medicine， providing scientific pharmaceutical service for clinical application of Rehmanniae Radix Preparata in future

[Key words]Li Shizhen； Rehmanniae Radix Praeparata； Jin Shiyuan； dispensing technology； pharmaceutical service

doi：10.4268/cjcmm20160930

熟地黄属于临床常用中药，是四维药之一[1]。其名最早见于宋代苏颂编撰的《本草图经》：“二月、八月采根，蒸三、二日令烂，暴干，谓之熟地黄”[2]。历代本草对熟地黄记载颇多、良莠不齐，本研究旨在分析李时珍对熟地黄的炮制历史源流、炮制方法、临床应用及国医大师金世元教授对熟地黄的临床调剂经验，继承发展熟地黄的临床调剂技术，为拓展熟地黄的临床应用以及实验研究提供有益的借鉴。……