章新根 蔡海英

[摘要]该文收集中国知网全文期刊数据库（CNKI）中中医药治疗多发性大动脉炎的文献，并对文献报道的方剂进行筛选、规范后，建立相应方剂数据库，运用中医传承辅助平台软件分析其中的用药规律。筛选治疗多发性大动脉炎的方剂共126首，中药212种，分析得到治疗多发性大动脉炎的常用药物、用药频次，演化得到核心组合26个，多发性大动脉炎治疗以益气养血、活血化瘀、温阳通络为主，并形成候选新方4个。在此基础上，利用挖掘的用药规律，结合多发性大动脉炎的病情特点，列举了2个临床实例，病例一表明了该研究用药模式的药物组合符合多发性大动脉炎的基础核心用药模式，是切合多发性大动脉炎的核心病机的，病例二辨证时体现了基于熵层次聚类的治疗多发性大动脉炎新方的药物组合特点，通过这2个临床案例的实践分析，进一步表明分析结果的可靠性。该研究对多发性大动脉炎中医临床治疗和中药新药研发均具有一定的指导意义和参考价值。

[关键词]多发性大动脉炎；中医传承辅助平台；组方规律

[Abstract]To collect the literature on traditional Chinese medicine treatment for multiple aortoarteritis from China National Knowledge Infrastructure（CNKI）， establish prescriptions database after screening and normalizing the prescriptions reported in these literature， and analyze their medicinal rules by using traditional Chinese medicine inheritance support system A total of 126 prescriptions for multiple aortoarteritis were screened， containing 212 kinds of Chinese herbs 26 core herb combinations were obtained by analysis of the commonly used herbs and their use frequencies The treatment for multiple aortoarteritis was manly of tonifying qi to nourish blood， promoting blood circulation to remove blood stasis， warming yang to dredge collaterals， and four new prescriptions were obtained On this basis， two clinical cases were taken as the examples by analyzing the medicinal rules and the features of multiple aortoarteritis The first case showed that the herb combination of this study conformed to the basic core drug application mode and the core pathogenesis of multiple aortoarteritis The second case reflected the characteristics of the new prescriptions′ herb combinations based on entropy hierarchical clustering The practical analysis of the two clinical cases further indicated the reliability of the results This study has certain guiding significance and reference value on new medicine research and development as well as clinical traditional Chinese medicine treatment for multiple aortoarteritis

[Key words]multiple aortoarteritis； traditional Chinese medicine inheritance support system； prescription rule

doi：10.4268/cjcmm20160929

多發性大动脉炎（Takayasu′s arteritis，TA）是主动脉及其主要分支的慢性进行性非特异性炎性动脉疾病，亦可累及肺动脉及其更远的外周动脉如腋动脉、肱动脉、股总动脉和股浅动脉等[12]。中医学将其归属为“无脉症”、“脉痹”、“血痹”等病范畴。随着对本病认识的不断深入，更多的病人被诊断出患有本病。因本病累及范围大，临床表现多样，并发症多，治疗难度大，已经越来越引起人们的重视。……