王光明



六味能消胶囊联合兰索拉唑、莫沙必利治疗反流性食管炎的临床效果研究

王光明

【摘要】目的 探讨六味能消胶囊联合兰索拉唑与莫沙必利治疗反流性食管炎的临床疗效。方法 152例研究对象均为2015年1～2016年3月我院体检科确诊的反流性食管炎患者，随机分为两组，研究组和对照组，每组各有76例，对照组给予兰索拉唑与莫沙必利治疗，研究组用六味能消胶囊联合兰索拉唑、莫沙必利治疗，对比临床疗效。结果 治疗后两组症状积分均较治疗前出现明显下降，差异有统计学意义（P＜0.05）；治疗后研究组的症状积分与对照组比较更低，差异有统计学意义（P＜0.05）。研究组总有效率与对照组比较更高，差异有统计学意义（P ＜0.05）。结论 反流性食管炎采用六味能消胶囊联合兰索拉唑、莫沙必利治疗效果更好，优势显著，优于应用兰索拉唑与莫沙必利治疗。

【关键词】反流性食管炎；六味能消胶囊；兰索拉唑；莫沙必利

Objective To investigate the clinical efficacy of Liu Wei Neng Xiao Capsule Combined with lansoprazole and mosapride in the treatment of reflux esophagitis. Methods From January 2015 to March 2016，152 cases of patients with esophagitis our hospital reflux were selected as the study subjects and were randomly divided into two groups，the study group and the control group，76 cases in each group. Control group received lansoprazole and mosapride，study group was treated with Liu Wei Neng Xiao capsule combined with lansoprazole and mosapride，to compare the clinical efficacy of two groups. Results After treatment，the symptom score decreased significantly compared with before treatment，the difference was statistically significant （P＜0.05）；The symptom score of study group was lower than that of control group after treatment，the difference was statistically significant （P＜0.05） . The total efficiency of the study group was higher than that of control group，the difference was statistically significant （P＜0.05）. Conclusion Application of Liu Wei Neng Xiao Capsule combined with lansoprazole and mosapride in the treatment of reflux esophagitis has significant effects，which is better than application of lansoprazole and mosapride.

【Key words】 Reflux esophagitis，Liu Wei Neng Xiao Capsule，Lansoprazole，Mosapride

反流性食管炎是一种慢性难治性疾病，主要是由于胃及十二指肠等内容物反流入食管而导致食管黏膜发生损伤，患者以反酸、烧心、胸骨后痛等为主要的临床表现，严重影响了患者的生活质量及生命健康［1-2］，近年来，随着人们生活水平的不断提高、生活方式的改变及生活节奏的不断加快，我国反流性食管炎的发生率呈现逐年升高的趋势。由于胃动力下降、胃酸分泌过多为反流性食管炎的发病机制，因此，在治疗方面多使用抑制胃酸药物及恢复胃动力药物，虽然可取得一定的效果，但是长时间使用复发率高［3］。……