黄恒星 漆伟征 张艳 龙德安

[摘要] 目的 对高脂血症性急性胰腺炎（HLAP）的临床特点进行分析研究。 方法 将高脂血症性胰腺炎患者32 例作为观察组，非高脂血症胰腺炎患者38例作为对照组，对其临床特征、生化指标等方面的差异进行回顾性分析。结果 观察组在发病年龄方面低于对照组，病程长于对照组，BMI水平高于对照组，糖尿病及过量酒精摄入患者所占比例高于对照组，差异均有统计学意义（P<0.05）。在甘油三酯（TG）、总胆固醇（TC）、天冬氨酸氨基转移酶（AST）、C反应蛋白（CRP）等实验室检查方面明显高于对照组，而血清淀粉酶（AMS）明显低于对照组，两组比较差异有统计学意义（P<0.05）。 结论 高脂血症性急性胰腺炎严重性与高脂血症有相关性，且发病不典型，治疗上降脂及改善代谢紊乱尤其重要。

[关键词] 高脂血症；胰腺炎；甘油三酯；总胆固醇；淀粉酶

[中图分类号] R657.5 [文献标识码] B [文章编号] 1673-9701（2016）09-0037-03

[Abstract] Objective To analyze and study the clinical characteristics of hyperlipidemic acute pancreatitis （HLAP）. Methods 32 patients with HLAP were selected as the observation group， and another 38 patients without HLAP were selected as the control group. Retrospective analysis and study were performed on the differences of clinical characteristics， biochemical indices and other aspects. Results The disease onset age in the observation group was lower than that in the control group， the course of the disease was longer than the control group， BMI level was higher than the control group， the rates of patients with diabetes and excessive alcohol intake proportion were higher than the control group， the difference was statistical significance （P<0.05）， and the laboratory examination indicators in the observation group， such as TG， TC， AST and CRP， were significantly higher than those in the control group， but AMS was significantly lower than that in the control group. There were significant differences compared between the two groups（P<0.05）. Conclusion The severity of HLAP is positive correlated to hyperlipidemia， and its onset is atypical. Therefore， it is especially important to reduce blood lipid and improve metabolic disorder in the treatment.

[Key words] Hyperlipidemia； Pancreatitis； Glycerol； Total cholesterol； Amylase

急性胰腺炎（acute pancreatitis，AP）是临床上尤其是消化内科及普通外科常见的急腹症之一，病因常见于胆道疾病、长期饮酒或者嗜洒、暴饮暴食、手术及应激状态、高钙血症、药物等，但随着人们的生活水平的显著提高，饮食结构的较大改变特别是高脂肪高蛋白饮食的大量摄入，加上生活节奏明显加快、工作生活压力的增大，体育锻炼的不足，高脂血症（hyperlipernia，HL）诱发的急性胰腺炎的发病率呈现明显上升趋势。该病由于其特殊的临床特点如早期表现不典型、发展较快、易合并及并发多种病症、较高的死亡率，引起了临床医生的高度重视，为患者迅速实施积极有效的诊疗措施显得非常的紧迫和必要[1]。本研究通过回顾性分析2014 年1月～2015年12月本院及协作医院收治的32例高脂血症性胰腺炎（HLAP）患者的临床病例资料，分析研究高脂血症性急性胰腺炎的临床特点。现具体报道如下。

1 资料与方法

1.1 一般资料……