余静珠+居健惠+孙锦贤+屠春林

摘 要 目的：观察疏风解毒胶囊联合桔芩汤治疗支气管扩张急性期的临床效果。方法：收集2014年1月至12月支气管扩张急性期患者58例，随机分为治疗组和对照组，每组29例。对照组采用西医常规治疗并口服阿莫西林克拉维酸钾分散片和厄多司坦胶囊；治疗组在对照组用药基础上，口服疏风解毒胶囊和桔芩汤汤剂。治疗15 d后比较两组疗效，并观察治疗前后患者的临床表现、圣乔治生活质量评分的变化情况。结果：治疗组总有效率为93.10%（27/29），对照组为72.41%（21/29），组间差异有统计学意义（P<0.05）。治疗组临床症状缓解时间较对照组明显缩短（P<0.05）。治疗后治疗组圣乔治呼吸问卷各部分评分均较治疗前降低（P<0.05），对照组呼吸症状、总评分治疗前后差异有统计学意义（P<0.05）。治疗后两组呼吸症状、总评分比较差异有统计学意义（P<0.05）。结论：疏风解毒胶囊和桔芩汤配合西医常规治疗支气管扩张急性期疗效显著，可以明显改善患者的临床症状及生活质量。

关键词 支气管扩张 疏风解毒胶囊 桔芩汤

中图分类号：R562.2+2 文献标识码：A 文章编号：1006-1533（2016）06-0024-04

Clinical observation of dispelling wind detoxification capsule and jieqin decoction in the treatment of 29 cases of bronchiectasis in the acute stage

YU Jingzhu， JU Jianhei， SUN Jinxian， TU Chunlin

（ 1. Xuhang Community Health Service Center of Jiading District， Shanghai 201809， China；

2. Central Hospital of Jiading District， Shanghai 201800， China）

ABSTRACT Objective： To observe the clinical efficacy of dispelling wind detoxification capsule and jieqin decoction in the treatment of bronchiectasis in the acute stage. Methods： Fifty-eight cases with bronchiectasis in the acute stage from Jan. to Dec. 2014 were collected and randomly divided into a treatment group and a control group with 29 cases each. The control group was treated with the conventional western therapy and oral amoxicillin clavulanate potassium dispersible tablet and erdosteine capsule. On the basis of the treatment as the control group， the treatment group was treated with dispelling wind detoxification capsule and jieqin decoction. The therapeutic effect was compared between the two groups after 15 days treatment， and the clinical manifestations of the patients and the change of St George life quality score were observed before and after the treatment. Results： The total effective rates were 93.10% （27/29） in the treatment group and 72.41% （21/29） and the control one， the differences between the two groups had the statistical significance （P<0.05）. The relief time of the clinical symptom in the treatment group was shorter than that of the control group （P<0.05）. Each part of the St George respiratory questionnaire scores was lower after treatment than before （P<0.05）. In the control group， the differences in the respiratory symptoms and the total scores had the statistical significance before and after the treatment （P<0.05）. After the treatment， the differences of the scores of the respiratory symptoms and total scores in the both groups had the statistical significance （P <0.05）. Conclusion： Combination of dispelling wind detoxification capsule and jieqin decoction with the conventional western therapy in the treatment of the bronchiectasis in the acute stage has the significant treatment effect， and can obviously improve the clinical symptoms and quality of the life of the patients.

KEY WORDS bronchiectasis； dispelling wind detoxification capsule； jieqin decoction

支气管扩张（简称支扩）是常见的肺组织结构破坏性疾病，由多种病因所致，以支气管不可逆扩张为特点。支扩常因合并下呼吸道感染而反复急性加重，表现为咳嗽增多、大量脓痰、咯血、气急甚至诱发呼吸衰竭。西医以抗生素为支扩急性期的基本治法，但长期使用抗菌药物是否能改善患者生活质量，目前尚缺乏大样本的随机对照临床试验证实[1]，而滥用抗生素易引起细菌耐药却不容置疑。中医认为，支扩乃经年宿疾，痰湿深伏难去，久郁必化热，辨证分型提示支扩急性期绝大多数呈现痰热类证候[2]。本研究在常规西医抗感染、排痰基础上加用清热化痰类中药组合治疗支扩急性期患者，观察是否能控制支气管感染情况，更快改善临床症状，从而提高患者生活质量。

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