游贤超(毕节市第一人民医院重症医学科，贵州 毕节　551700)



乌司他丁治疗感染性休克的疗效观察

游贤超*(毕节市第一人民医院重症医学科，贵州 毕节551700)

DOI10.14009/j.issn.1672-2124.2016.02.009

摘要目的：探讨乌司他丁治疗感染性休克的临床疗效。方法：选取毕节市第一人民医院2012年12月—2014年12月收治的280例感染性休克患者，按随机数字表法分为2组各140例，对照组患者进行常规治疗，观察组患者在此治疗基础上联合乌司他丁治疗，并对2组患者多器官功能障碍产生病例数，死亡病例数，重症监护室(ICU)住院时间，患者复苏时间，抗感染药物使用时间及治疗费用进行比较。结果：观察组患者出现多器官功能障碍64例(45.71%)、死亡40例(28.57%)，ICU住院时间(10.97±3.16) d，复苏时间为(6.32±0.45) d，治疗费用为(3.51±0.12)万元，与对照组的106例(75.71%)，52例(37.14%)，(16.47±3.28) d，(8.57±0.73) d，(4.22±0.16)万元比较，差异有统计学意义(P<0.05)。而2组患者抗感染药物使用时间均为7 d，2组的差异无统计学意义(P>0.05)。结论：乌司他丁治疗感染性休克可提高其疗效，明显降低患者的死亡率，具有重要的临床应用价值。

关键词乌司他丁； 感染性休克； 疗效

Observation on Efficacy of Ulinastatin in Treatment of Septic Shock

YOU Xianchao(Dept.of Respiratory and Critical Care Medicine, the First People’s Hospital of Bijie, Guizhou Bijie 551700, China)

ABSTRACTOBJECTIVE：To investigate the clinical efficacy of ulinastatin in treatment of septic shock. METHODS: 280 cases with septic shock admitted into the First People’s Hospital of Bijie from Dec. 2012 to Dec. 2014 were selected to be divided into two groups via the random number table, with 140 cases in each. The control group were treated with conventional treatment while the observation group additionally received ulinastatin based on the control group; the number of multiple organ dysfunction, death toll, length of stay in ICU, patient’s recovery time, application time of anti-infective drugs and treatment cost were compared between two group of patients. RESULTS: In observation group, the number of multiple organ dysfunction were 64 cases(45.71%), death toll were 40 cases(28.57%), length of stay in ICU were (10.97±3.16) d, patient’s recovery time were (6.32±0.45) d and treatment costs were (3.51±0.12) ten thousand yuan; while in control group these were 106 cases(75.71%), 52 cases(37.14%), (16.47±3.28) d, (8.57±0.73) d, (4.22±0.16) ten thousand yuan; there were statistically significance between two group of patients (P<0.05). The application time of anti-infective drugs in two groups were 7 d, with no statistically significant difference (P>0.05). CONCLUSIONS: Ulinastatin in treatment of septic shock can improve the clinical efficacy, significantly decrease the death toll of patients, and has essential clinical application value.

KEYWORDSUlinastatin; Septic shock; Efficacy

感染性休克常会导致患者出现心功能不全、心律失常等相关症状，是危重病患者在临床治疗过程中最为常见的死亡因素，有效的治疗则十分重要[1-2]。本研究观察了乌司他丁治疗感染性休克的疗效，现报告如下。

1资料与方法

1.1资料来源

选取毕节市第一人民医院2012年12月—2014年12月收治的感染性休克患者280例，按随机数字表法分为2组各140例，对照组患者中，男性92例，女性48例，年龄35～75岁，平均年龄(51.5±3.3)岁；消化性溃疡穿孔64例，化脓性阑尾炎20例，坏疽性胆囊炎18例，外伤性肠穿孔16例，肺部感染12例，坏死性胰腺炎10例。……