吴明杰(江苏省沛县中医院药剂科，江苏 徐州　221600)



住院患者注射用质子泵抑制剂不合理应用分析

吴明杰*(江苏省沛县中医院药剂科，江苏 徐州221600)

DOI10.14009/j.issn.1672-2124.2016.02.040

摘要目的：分析沛县中医院(以下简称“我院”)住院患者不合理应用注射用质子泵抑制剂(proton pump inhibitors,PPI)的情况。方法：采用回顾性研究方法，通过查阅电子病历、医嘱、检验结果等，采集随机选取的480例注射用PPI患者的相关信息进行研究。结果：480例病例中，注射用PPI使用不合理246例，合格率为48.75%；外科不合理应用情况明显高于内科，分别为56.91%和43.09%；注射用PPI使用不合理最主要的原因为用药指征不明确，其次为使用疗程偏长、药物超剂量使用以及药物之间存在相互作用。结论：我院住院患者注射用PPI临床合理用药情况有待提升，应该综合考虑各科室药物使用的多方面因素，制订规范的注射用PPI使用标准，以提高我院合理用药水平。

关键词质子泵抑制剂； 合理用药； 分析

Analysis on irrational application of proton pump inhibitors for injection in patients

WU Mingjie(Dept.of Pharmacy, Hospital of Traditional Chinese Medicine of Jiangsu Pei County, Jiangsu Xuzhou 221600, China)

ABSTRACTOBJECTIVE：To analyze the irrational application of proton pump inhibitors(PPIs) for injection in inpatients in Hospital of Traditional Chinese Medicine of Jiangsu Pei County(hereinafter referred to as “our hospital”). METHODS: Retrospective investigation was adopted, the related information of 480 randomly collected patients with PPIs was researched through consulting the electronic medical records, doctor’s advice, inspection, etc. RESULTS: Of the 480 cases, 246 cases with application of PPI were irrational, the qualified rate was 48.75%; and the irrational application phenomenon in surgical department were more serious than in internal medicine, respectively 56.91% and 43.09%. The irrational application of PPI mainly caused by unapparent medication indications, followed by long course of treatment, over dosage of medication and drug interactions. CONCLUSIONS: The irrational application of PPI in inpatients in our hospital still need to be improved, it is necessary to synthetically consider various factors of drug use in different departments and establish application standards of PPI, so as to improve rational drug use in our hospital.

KEYWORDSProton pump inhibitors; Rational drug use; Analysis

质子泵抑制剂(proton pump inhibitors,PPI)通过阻碍胃壁细胞H+K+-ATP酶发挥作用，可有效抑制胃酸分泌，是目前最有效的抗溃疡药物[1]。近年来，PPI逐渐由消化系统用药扩展到外科领域，其使用量逐年增加，因此对PPI的临床应用情况进行分析，对促进临床用药的科学性和安全性具有重要的意义[2]。本调查分析江苏省沛县中医院(以下简称“我院”)住院病区注射用PPI的使用情况，现报告如下。

1资料与方法

1.1资料来源

选取我院住院病区2014年1月—2015年1月内、外各科室480例应用注射用PPI的住院病例作为研究对象。其中，内科和外科各240例，男性263例，女性217例，平均年龄(52.8±16.2)岁，注射用PPI平均使用时间(7.6±6.3) d。……