彭思萃　吴建谷　张新树

[摘要] 目的 分析中药方剂联合雷公藤多苷治疗小儿紫癜性肾炎的效果。 方法 选择2013年6月～2015年6月广东省揭西县人民医院诊治的紫癜性肾炎患儿82例，将其随机分为研究组与对照组，每组患儿41例。两组均给予基础治疗，对照组给予雷公藤多苷片，观察组在对照组基础上结合中药方剂治疗。两组疗程均为4周。比较两组患儿尿β2-MG、血β2-MG、24 h尿蛋白定量水平，治疗效果及不良反应。 结果 治疗后研究组患者的尿β2-MG、血β2-MG、24 h尿蛋白含量分别为（0.13±0.04）μg/L、（1.84±0.37）μg/L、（1.85±0.54）g/L，对照组的分别为（0.29±0.06）μg/L、（2.25±0.40）μg/L、（2.79±0.67）g/L，均较治疗前明显下降（P<0.05）；治疗后研究组尿β2-MG、血β2-MG、24 h尿蛋白定量水平低于对照组，差异有统计学意义（P<0.05）；研究组和对照组治疗总有效率分别为92.68%和70.73%，两组比较差异有统计学意义（P<0.05）；两组均未出现严重用药不良反应。 结论 中药方剂联合雷公藤多苷治疗小儿紫癜性肾炎的疗效显著。

[关键词] 中药方剂；雷公藤多苷；小儿紫癜性肾炎

[中图分类号] R554+.6 [文献标识码] A [文章编号] 1674-4721（2016）02（c）-0103-03

[Abstract] Objective To analyze the effect of Chinese medicine formulae combined with Tripterygium glycosides in treating purpura nephritis in children. Methods 82 children with purpura nephritis from July 2013 to July 2015 of Jiexi county people′s hospital in Guangdong province were selected and were randomly divided into study group and control group.Each group was 41 cases.All patients were treated with basic treatment.Patients in control group were treated with Tripterygium glycosides tablet.Patients in study group were given Chinese medicine formulae on the basis of control group.4 weeks was a course between two groups.Urine β2-MG，blood β2-MG，24 h urine protein quantitative level，therapy effect and adverse effect were compared between two groups. Results After treatment，the urine β2-MG，blood β2-MG and 24 h urine protein quantitative level in study group and control group was respectively（0.13±0.04）μg/L，（1.84±0.37）μg/L，（1.85±0.54）g/L，（0.29±0.06）μg/L，（2.25±0.40）μg/L and （2.79±0.67）g/L，significantly decreased than before treatment（P<0.05）.After treatment，the urine β2-MG，blood β2-MG and 24 h urine protein quantitative level in study group was obvious lower than that of control group respectively（P<0.05）.The total effective rate in study group and control group was respectively 92.68% and 70.73%，and the difference was statistical significance（P<0.05）.Any severe adverse effects appeared in two groups. Conclusion Chinese medicine formulae combined with Tripterygium glycosides has obvious effects in treating purpura nephritis in children.

[Key words] Chinese medicine formulae；Tripterygium glycosides；Purpura nephritis in children

过敏性紫癜是儿科常见的一种疾病，主要表现为皮肤紫癜、便血、腹痛及关节肿痛，常会累及肾脏而形成紫癜性肾炎[1-2]。紫癜性肾炎病程有迁延倾向，是小儿慢性肾衰竭的主要病因之一[3]。目前，临床上对于小儿紫癜性肾炎尚无特效治疗方法，仅以对症治疗为主，疗效不甚理想。需要注意的是，治疗小儿紫癜性肾炎时需要保护患儿的肾功能。随着中医药在小儿紫癜性肾炎治疗中的广泛应用，其疗效值得肯定[4]。本文旨在分析中药方剂联合雷公藤多苷对我院纳入紫癜性肾炎患儿的治疗效果。

1 资料与方法

1.1 一般资料

选择2013年6月～2015年6月广东省揭西县人民医院诊治的紫癜性肾炎患儿82例。诊断均依据中华医学会儿科学分会肾脏病学组制定的《紫癜性肾炎的诊断与治疗（草案）》[5]中关于紫癜性肾炎标准。……