作者单位：200000 上海，同济大学医学院(徐铖秀)；200170 上海，上海青浦区盈浦社区卫生服务中心(徐铖秀，张志澄)；215000 苏州，苏州大学第二附属医院(许程玥)

自拟平喘合剂对稳定期慢性阻塞性肺疾病临床疗效观察

徐铖秀张志澄许程玥

【摘要】目的观察自拟平喘合剂治疗稳定期COPD的临床疗效。方法收集100例中、重度COPD患者，随机分为观察组和对照组各50例，对照组使用常规西医治疗，观察组在常规治疗的基础上加用自拟制剂平喘合剂治疗，6个月后观察综合疗效、肺功能和运动耐力的改善情况。结果治疗6个月后，2组患者的综合疗效相近(P>0.05)，但观察组的FEV1%、FEV1占预计值百分比和6 min步行距离均比对照组明显改善(P均<0.05)。结论自拟平喘合剂能明显改善中、重度COPD患者的肺功能和运动耐力，有助改善COPD患者的生活质量。

【关键词】平喘合剂；慢性阻塞性肺疾病；中西医结合

DOI：10.3969/g.issn.0253-9802.2015.02.009

通讯作者，张志澄，E-mail: zhang_zc77@hotmail.com

收稿日期：(2014-09-12)

Clinical observation of the efficacy of Pingchuan mixture in treatment of stable chronic obstructive pulmonary diseaseXuChengxiu,ZhangZhicheng,XuChengyue.MedicalSchoolofTongjiUniversity,Shanghai200000,China

Correspondingauthor,ZhangZhicheng,E-mail:zhang_zc77@hotmail.com

Abstract【】ObjectiveTo observe the clinical efficacy of Pingchuan mixture in treating moderate and severe chronic obstructive pulmonary disease (COPD). MethodsIn total, 100 patients diagnosed with moderate or severe COPD were randomly divided into the observation group(n=50) and control groups (n=50). Patients in the control group were treated with conventional medical methods, while their counterparts in the observation group were supplemented with Pingchuan mixture based on the conventional medical methods. The improvement in comprehensive efficacy, pulmonary function and exercise tolerance was statistically compared between the two groups after 6-month treatment. ResultsThe comprehensive efficacy showed no significant difference between the two groups (P>0.05). However, the FEV1/FVC%, FEV1 % predicted and 6-minute walking distance in the observation group were significantly improved compared with those in the control group (all P<0.05). ConclusionPingchuan mixture could improve the pulmonary function and exercise tolerance in patients with moderate or severe COPD, thereby contributing to improving the quality of life of COPD patients.

【Key words】Pingchuan mixture; Chronic obstructive pulmonary disease;

Integrated traditional Chinese and western medicine

COPD是一种以气流受限为特征的疾病，气流受限不完全可逆、呈进行性发展，主要临床表现为咳嗽、咳痰、呼吸困难。COPD稳定期患者除通气和氧合功能受损外，还容易发生呼吸肌疲劳，随之出现的咳、痰、喘等症状，严重影响患者的日常生活，加重了其生理负担，降低其生活质量[1]。现代医学对COPD的治疗不仅强调急性发作期的救治，更重视缓解期的调理，着重强调对患者生活质量的改善[2]。多项研究表明，采用传统中医药或中西医结合治疗，在改善COPD患者症状、减少急性加重发作次数、提高运动能力和生活质量等方面具有较好的疗效，并且其疗效均优于单纯西医治疗[3-5]。近年笔者以自拟制剂平喘合剂治疗中、重度稳定期COPD患者，取得良好的疗效，现报告如下。