付郁

[摘要] 目的 研究宫颈人乳头瘤病毒（HPV）检测联合薄层液基细胞血（TCT）筛查对宫颈癌患者病变前筛选中的临床意义。方法 整群选取该院2012年2月—2013年4月收治的60例宫颈异常且后期诊断为宫颈癌病变患者，均采用TCT检测、HPV联合TCT检测对患者宫颈癌病变前筛选，回顾性分析两种方法检测结果。结果 HPV联合TCT检测阳性检出率95.0%相较TCT检测80.0%显著较高，差异有统计学意义（P<0.05），相较后期病变临床检测结果差异无统计学意义（P>0.05）；TCT检测阳性检出率80.0%相较后期病变临床检测显著较低，差异有统计学意义（P<0.05）。结论 HPV联合TCT检测能有效筛查宫颈癌病变前，具有临床推广价值。

[关键词] HPV；TCT；宫颈癌

[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2015）11（c）-0040-02

[Abstract] Objective To study the clinical significance of cervical human papillomavirus （HPV） detection combined with thin layer liquid based cell blood （TCT） screening in the screening of patients with cervical precancerous lesion. Methods 60 cases with cervical abnormality diagnosed as cervical cancer patients in the later stage in our hospital from February 2012 to April 2013 were selected and given TCT detection and HPV detection combined with TCT detection for the screening of cervical precancerous lesions in patients， and the results of the two methods were retrospectively analyzed. Results The positive detection rate of HPV combined with TCT detection was 95.0%， which was significantly higher than 80.0% by TCT detection， the difference was statistically significant（P<0.05）；there was no obvious difference between the positive detection rate of HPV combined TCT detection and clinical test results of lesions in later stage， which was not statistically significant（P>0.05）； the positive detection rate（80.0%） of TCT detection was significantly lower than that in the later stage， which was statistically significant （P<0.05）. Conclusion HPV combined with TCT detection can effectively screen cervical precancerous lesions， which is worthy of clinical popularization.

[Key words] HPV； TCT； Cervical cancer

宫颈癌是女性生殖道常见的恶心肿瘤疾病，人乳头瘤病毒是宫颈癌发病的主要因素，宫颈癌症状有宫颈糜烂、肥大、溃疡以及乳头样增生等，尽早检查对及时有效治疗和预防癌病变尤为重要[1-2]。该院整群选取2012年2月—2013年4月收治的60例宫颈异常且后期诊断为宫颈癌病变患者分别TCT检测、HPV联合TCT检测，回顾性分析检测结果，研究宫颈HPV检测联合TCT筛查对宫颈癌患者病变前筛选中的临床意义，现报道如下。

1 资料与方法

1.1 一般资料

整群选取该院收治的60例宫颈异常且后期诊断为宫颈癌病变患者，后期临床检测低度鳞状上皮内病变（LSIL）41例，高度鳞状上皮内病变（HSIL）19例。患者年龄24～58岁，平均年龄（34.2±4.1）岁，病程2个月～1年，平均病程（0.6±0.2）年，临床症状为宫颈糜烂、宫颈肥大、乳头样增生等症状。

1.2 方法

TCT检测：妇产科医师使用武汉成龙科贸有限公司生产的TCT-10宫颈采样器采集患者宫颈外及宫颈口的脱落细胞，将采样刷放入……