杨世俊

[摘要] 目的 探讨观察短时受精在体外受精技术中的临床效果。方法 整群选取2011年10月1 日—2014年5月31日在该院接受体外受精的245例不孕患者，入组患者夫妇进行体格检查后，均行超促排卵、取卵，将患者随机分成实验组和对照组，其中对照组120例采用传统常规受精方法，实验组125例采用短时受精方法，观察两组患者治疗的临床效果。结果 实验组的卵裂率、正常受精率和优质胚胎率与对照组的无明显差异，差异无统计学意义（P>0.05）；实验组患者的妊娠率明显高于对照组，差异有统计学意义（P<0.05）。 结论 短时受精在体外受精大大的提高了卵子的利用率，临床上在不影响周期正常受精率的前提下提供了更多的优质胚胎，在临床上可以广泛运用。

[关键词] 短时受精；体外受精；优质胚胎率

[中图分类号] R725 [文献标识码] A [文章编号] 1674-0742（2015）11（c）-0032-03

[Abstract] Objective To investigate the clinical effect of short-term fertilization in in vitro fertilization technique. Methods A total of 245 infertility cases underwent in vitro fertilization in our hospital from 2011 October 1st to 2014 May 31st were selected. Superovulation and taking ovum were performed in the selected couples after the physical examination. The patients were randomly divided into the experimental group（125 cases） and the control group（120 cases）. Patients in the control group were treated by the traditional routine fertilization method， while those in the experimental group were treated by the short-term fertilization. And the clinical effects of the two groups were observed. Results The differences in the cleavage rate， normal fertilization rate， and high-quality embryo rate between the experimental group and the control group were not statistically significant（P>0.05）. The rate of pregnancy in the experimental group was significantly higher than that in the control group with statistically significant difference（P<0.05）. Conclusion Short-term fertilization applied to in vitro fertilization greatly improves the utilization rate of the ovum， so that more high-quality embryos can be provided without affecting the normal fertilization rate clinically， so it can be widely used.

[Key words] Short-term fertilization； In vitro fertilization； High-quality embryo rate

近几年来随着不健康食物、辐射种类的增多，更多的男女易患上不孕不育[1]。越来越多的医生学者致力于研究体外受精技术，为了提高胚胎的优质数量和临床妊娠率，防止受精周期完全失败，受精周期的长短在其中起到了关键的作用[2]。越来越多的医院采用了短时受精方法，由于在国内短时受精还在探讨阶段，该院为进一步探讨观察并分析短时受精在体外受精技术中的临床效果，特整群选取2011年10月1日—2014年5月31日年间收治的245例不孕患者的临床资料，现报道如下。

1 资料与方法

1.1 一般资料

整群选取在该院接受体外受精治疗的245例患有不孕不育的患者，入组患者夫妇进行体格检查后均确诊为为不孕患者，并将其随机分成两组。

其中对照组120例采用传统受精，女方年龄21～42岁，平均年龄（29.2±7.3）岁，男方精液正常的患者75例，精液不正常的患者45例，不孕年限2～9年，平均不孕年限（4.2±1.3）年；实……