补肾健脾方对围绝经期及绝经期肥胖妇女体质量及性激素水平的影响

史志萍刘霄霞陆君1李英卢丽王静馥李焕丽薛有平2

(河北省秦皇岛军工医院妇产科，河北秦皇岛066001)

【摘要】目的观察补肾健脾方对围绝经期及绝经期肥胖妇女体质量及性激素水平的影响，并探讨体质量指数(BMI)与性激素水平之间的相关性。方法将本院体检的120例围绝经期及绝经期肥胖妇女随机分为2组。治疗组60例采用补肾健脾中药口服治疗，对照组不予治疗。比较2组体质量、BMI、腰围、臀围、腰臀比及血清雌二醇(E2)、卵泡刺激素(FSH)及黄体生成素(LH)水平。结果治疗组用药后，BMI、腰臀比较用药前均下降(P<0.01，P<0.05)，且与照组同期比较改善明显(P<0.01)。治疗组用药后E2水平明显升高(P<0.01)，FSH、LH水平均降低(P<0.01)，且与对照组同期比较改善明显(P<0.01)。结论补肾健脾方能降低围绝经期及绝经期妇女的BMI及腰臀比，能改善其性激素水平。

【关键词】补肾；健脾；围绝经期；绝经期；肥胖症；人体质量指数；雌激素类；中药疗法

doi：10.3969/j.issn.1002-2619.2015.04.006

【中图分类号】R271.116；R589.250.531

【文献标识码】A

【文章编号】1002-2619(2015)04-0497-04

作者简介：史志萍(1962—)，女，副主任医师。研究方向：妇科内分泌系统疾病的治疗。

Abstract【】ObjectiveTo observe the effects of tonifying kidney and spleen herbs on body mass and sex hormone levels in perimenopause and menopause women with obesity, and to study the relativity between body mass index (BMI) and sex hormone levels.Methods120 perimenopause and menopause women with obesity who had physical examination in our hospital were divided into two groups.60 cases in treatment group were received oral tonifying kidney and spleen herbs, the control group received no treatment.The body mass, BMI, waist circumference, hip circumference, waist-hip ratio and the level of serum estradiol (E2), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were compared in two groups.ResultsAfter treatment in treatment group, BMI and waist-hip ratio were decreased compared with those in before treatment (P<0.01，P<0.05), and the improvement was more significant compared with that in control group at the same period (P<0.01).The level of E2 after treatment in treatment group was significantly increased compared with that in before treatment (P<0.01), the level of FSH and LH were decreased (P<0.01), and the improvement was more significant compared with that in control group at the same period (P<0.01).ConclusionTonifying kidney and spleen herbs can decrease the BMI and waist-hip ratio in perimenopause and menopause women with obesity, improve the level of sex hormone.

收稿日期：(2012-05-03)

1河北省秦皇岛军工医院中医科，河北秦皇岛066001

2河北省秦皇岛军工医院检验科，河北秦皇岛066001

Effect of tonifying kidney and spleen herbs on body mass and sex hormone levels in perimenopause and menopause women with obesitySHIZhiping*,LIUXiaoxia,LUJun,etal.*Departmentofgynaecologyandobstetrics,QinhuangdaoMilitaryHospitalinHebeiProvince,Hebei,Qinhuangdao066001

【Key words】Tonifying kidney; tonifying spleen; perimenopause; menopause; obesity; body mass index; estrogens; traditional Chinese medicine therapy

围绝经期女性由于卵巢功能的衰退，活动量减少，基础代谢降低，造成热量过剩及糖代谢紊乱引起肥胖。有研究表明，围绝经期妇女的瘦素及胰岛素水平，肥胖者最高，非肥胖者次之，且非肥胖者瘦素、胰岛素水平亦比正常育龄妇女高；同时围绝经期妇女低密度脂蛋白、胆固醇、甘油三酯也均高于正常育龄妇女[1]。另外，女性进入围绝经期，雌激素分泌减少，而肾上腺皮质功能代谢性亢进，糖皮质激素分泌增加，促进脂肪吸收和储存，形成“发福型”体型[2]。……