泻火止痛方治疗肝火上炎型偏头痛的临床研究

陈 敏,黄宁静,王祎晟

摘要:目的 观察泻火止痛方治疗肝火上炎型偏头痛的临床疗效。方法 选择符合偏头痛诊断标准,且属于中医肝火上炎证型的患者108例,随机分为治疗组(55例)与对照组(53例)。治疗组予泻火止痛方颗粒,每日1包,分2次口服;盐酸氟桂利嗪胶囊模拟剂5 mg,每晚1次口服。对照组予泻火止痛方颗粒模拟剂,每日1包,分2次口服;盐酸氟桂利嗪胶囊5 mg,每晚1次口服。两组疗程均为8周。观察治疗前后两组临床疗效、中医证候疗效、偏头痛积分、中医证候积分。结果 治疗组临床疗效总有效率为87.27%,对照组总有效率为79.25% ,两组比较差异有统计学意义(P<0.01)。两组治疗后偏头痛积分较治疗前均有下降(P<0.01),偏头痛积分改善情况治疗组优于对照组(P<0.01)。治疗组中医证候疗效总有效率为89.09% ,对照组总有效率为75.47% ,两组比较差异有统计学意义(P<0.05);两组在治疗后中医证候积分较治疗前均有下降(P<0.01),中医证候积分改善情况治疗组优于对照组(P<0.01)。结论 泻火止痛方治疗辨证属于肝火上炎证型的偏头痛,具有良好的临床疗效。

关键词:偏头痛;清肝泻火;泻火止痛方;中医证候积分

中图分类号:R747.2 R259

文献标识码:A

doi:10.3969/j.issn.1672-1349.2015.12.006

文章编号:1672-1349(2015)12-1375-03

基金项目:上海市卫生局中医药科研基金(No.2012L040A)

通讯作者:王祎晟,E mail:8342@szy.sh.cn

Abstract:Objective To investigate the clinical effect of Xiehuo Zhitong decoction(XZD)in treating migraine with liver fire ascending syndrome.Methods One hundred and eight patients with migraine and liver fire ascending syndrome were randomly divided into two groups:Control group(n=53)treated by flunarizine hydrochloride plus simulation agents of XZD,and treatment group(n=55)treated by XZD plus simulation agents of flunarizine hydrochloride for 8 weeks.The total effective rate,the effective rate of symptom score,scores of migraine and the symptom scores of traditional Chinese medicine(TCM)were observed.Results After 8 weeks of treatment,the total effective rate was 87.27% in treatment group and 79.25% in control group(P<0.01).The scores of migraine were improved after treatment in both group,with more significant improved in treatment group than in control group(P<0.01).The effective rate of symptom score was 89.09% in treatment group and 75.47% in control group(P <0.05).The symptom scores were improved after treatment in both group,with more significant improved in treatment group than in control group.Conclusion XZD is quite effective in treating migraine with liver fire ascending syndrome.

收稿日期:(2015 03 18)

作者单位:上海中医药大学附属市中医医院(上海200071)

Clinical Observation on Xiehuo Zhitong Decoction in Treatment of Migraine with Liver fire Ascending Syndrome

Chen Min,Huang Ningjing,Wang Yisheng

Shanghai Hospital of Traditional Chinese Medicine,Shanghai 200071,China

Corresponding Author:Wang Yisheng

Key words:migraine;Xiehuo Zhitong decoction;liver fire ascending syndrome;symptom scores of traditional Chinese medicine

偏头痛为临床常见的慢性神经血管性疾病,对患者的生活质量影响很大,反复发作还可导致神经系统的损害。西药针对偏头痛急性治疗和预防治疗的用药都有较大副反应,而中药制剂确有其独特的疗效。从清肝泻火、化瘀止痛立论,不仅能治疗偏头痛急性发作,而且能有效防止偏头痛复发,且无毒副反应。这已在前期研究中得以证实。本研究将泻火止痛汤制成颗粒剂,同时扩大样本量,采用随机、对照、双盲、双模拟的研究方法,治疗肝火上炎型偏头痛,现报道如下。……