72例新生儿惊厥临床诊治分析

张晋雷

南阳医学高等专科学校第一附属医院儿科，河南南阳473000

[摘要]目的探究新生儿惊厥的临床诊断方法和治疗措施。方法整群选择该院2014年2月—2015年2月收治的72例新生儿惊厥患者，分为观察组、对照组，各36例。采用血液生化、脑电图、CT和磁共振以及头颅CT对患儿进行临床诊断；对照组给予地西沣静脉滴注，观察组给予利卡多因治疗。对比两组临床疗效、止惊时间以及神经行为评分情况。结果观察组治疗总有效率为83.33%（30/36），显著高于对照组的47.22%（17/36），差异有统计学意义（P＜0.01）。观察组止惊时间显著短于对照组，差异有统计学意义（P＜0.01）。观察组在治疗后1~7 d和10~12 d的神经行为评分显著高于对照组，差异有统计学意义（P＜0.01）。结论对于新生儿惊厥患儿采用利卡多因治疗具有显著疗效，且能够有效提高神经行为评分，值得临床推广。

[关键词]新生儿惊厥；诊断；治疗

[中图分类号]R722.1

[文献标识码]A

[文章编号]1674-0742（2015）10（a）－0066-03

[作者简介]张晋雷（1981-）,男，河南南阳人，硕士研究生，主治医师，研究方向：新生儿危重症救治及管理。

Abstract[]Objective To explore the clinical diagnosis and treatment of neonatal seizures.Methods 72 patients with neonatal seizures admitted to the hospital between February 2014 and February 2015 were divided into observation group and control group with 36 in each one.Blood biochemistry examination, EEG examination EEG, CT and MRI, and head CT scan were performed for the diagnosis; the control group was treated with intravenous drip of diazepam, while the observation group underwent intravenous drip of lidocaine.The clinical efficacy, the convulsion vanishing time, behavioral neurological assessment were compared between the two groups.Results The total effective rate was 83.33% (30/36) in the observation group, significantly higher than the 47.22% (17/36) in the control group, and the difference was significant (P<0.01).The convulsion vanishing time was shorter in the observation group than in the control group, and the difference was statistically significant, P＜0.01.The behavioral neurological assessment 1-7 day after treatment and that 10-12 d after treatment were both higher in the observation group than in the control group, and the differences were statistically significant, P＜0.01.Conclusion Lidocaine can produce remarkable effect in treating neonatal seizures and can improve the behavioral neurological assessment, therefore it is worthy of promotion in clinical practice.

Clinical Diagnosis and Treatment of Neonatal Seizures: An Analysis of 72 Cases

ZHANG Jin-lei

Department of Pediatrics, First Affiliated Hospital of Nanyang Medical College, Nanyang, Henan Province, 473000 China

[Key words]Neonatal seizures; Diagnosis; Treatment

新生儿惊厥是一种新生儿时期最为常见的临床症状，其主要是因为多种疾病所产生的神经系统症状[1]。新生儿惊厥对于患儿后期发展具有显著的影响，并且新生儿惊厥会增加患儿的脑损伤，严重者会导致遗留神经系统后遗症[2]。因此需要给予患者早期准确诊断并进行相应的治疗措施，避免并发症的发生。在该次研究中整群选择该院2014年2月—2015年2月间收治的72例新生儿惊厥患者，分别给予患者地西沣静脉滴注和利卡多因治疗，对比两组临床疗效，现报道如下。……