覃祖云等

摘要： 目的 ：对比异甘草酸镁、还原型谷胱甘肽两种药物在预防肝癌血管栓塞术后肝损害的效果。方法： 选择在我科住院的原发性肝癌病人95例为研究对象，根据入院时间单双日分为两组，A组61例使用还原型谷胱甘肽、B组34例使用异甘草酸镁进行预防。观察指标 术前、术后3天两组病例肝功能的对比。结果： 两组术前总胆红素对比有显著差异（P=0.0494），白蛋白对比有显著差异（P=0.4251），谷丙转氨酶对比无显著差异（P=0. 5644），谷草转氨酶对比有显著差异（P=0. 2120），凝血酶原时间对比无显著差异（P=0. 9772）；两组术后总胆红素对比有显著差异（P=0.0205），白蛋白对比有显著差异（P=0.2502），谷丙转氨酶对比有显著差异（P=0. 0195），谷草转氨酶对比有显著差异（P=0. 0062），凝血酶原时间对比无显著差异（P=0. 5105）。结论： 异甘草酸镁在预防肝癌血管栓塞术后肝损害的效果稍优于还原型谷胱甘肽。

关键词： 異甘草酸镁 还原型谷胱甘肽 肝癌血管栓塞术 肝功能 预防

Abstract： objective to compare different magnesium glycyrrhizic acid and reduced glutathione two drugs in the prevention of liver cancer vascular embolization of postoperative liver damage effect. Methods 95 cases with primary liver cancer patients hospitalized in our department as the research object， according to admission time ChanShuangRi divided into two groups， A group of 61 cases with reduced glutathione， B group of 34 cases using different glycyrrhizic acid magnesium for prevention. Observation indexes of preoperative and postoperative 3 days two groups of cases of liver function. Results two groups of preoperative total bilirubin compared with significant difference （P = 0.0494）， albumin contrast significant differences （P = 0.4251）， alanine aminotransferase compared to no significant difference （P = 0. 5644）， aspertate aminotransferase compared with significant difference （P = 0. 2120）， prothrombin time compared with no significant difference （P = 0. 9772）； Two groups of postoperative total bilirubin compared with significant difference （P = 0.0205）， albumin contrast significant differences （P = 0.2502）， alanine aminotransferase compared with significant difference （P = 0. 0195）， aspertate aminotransferase compared with significant difference （P = 0. 0062）， prothrombin time compared with no significant difference （P = 0. 5105）. Conclusion different glycyrrhizic acid magnesium in preventing postoperative liver damage liver vascular embolism was slightly better than the effect of reduced glutathione.

Keywords： glycyrrhizic acid magnesium Reduced glutathione liver vascular embolization Liver function is to prevent

目前原发性肝癌的治疗以综合治疗为主，其中肝癌血管栓塞术是微创手术较常用的方法，但肝癌血管栓塞术常引起肝功能的损害，甚至肝衰竭的发生，在临床工作中常使用异甘草酸镁注射液、还原型谷胱甘肽粉针剂进行保肝治疗，均取得较好的效果，为预防肝癌血管栓塞术后出现肝损害，本研究选择常用的2种保肝药进行术前用药对比。经对比发现异甘草酸镁注射液在预防肝癌血管栓塞术后出现肝损害的效果稍优于还原型谷胱甘肽粉针剂。现报告如下：

资料与方法