杨正乾

【摘 要】目的：探讨左氧氟沙星和头孢哌酮钠治疗老年尿路感染的疗效。方法：收集2012年至今于我院诊断为尿路感染的老年患者作为本次研究对象，按随机号码表法分为两组，25例研究组和25例对照组，研究组接受头孢哌酮钠治疗，对照组接受左氧氟沙星治疗。对比研究组和对照组尿路感染治疗的有效率及不良反应发生情况。结果：①研究组和对照组尿路感染治疗的有效率分别为100%、88%，差异有统计学意义（P<0.05）。②研究组发生1例抗生素相关腹泻，对照组发生2例皮疹、1例恶心。研究组和对照组不良反应发生率分别为4%、12%，差异有统计学意义（P<0.05）。结论：本次研究认为；相对于左氧氟沙星，头孢哌酮钠治疗老年尿路感染的疗效更为肯定，使用安全。

【关键词】老年；尿路感染；左氧氟沙星；头孢哌酮钠

Drug treatment of urinary tract infections in elderly patients： efficacy comparison between levofloxacin and cefoperazone sodium

Yang Zhengqian

Tongjiang County People's Hospital， Tongjiang， Sichuan 636700

[Abstract]Objective： To investigate the curative effect of levofloxacin and cefoperazone sodium in treatment of elder patients with urinary tract infection. Methods： Elder patients with urinary tract infection treated by our hospital during 2012 to date were randomly selected as the research object. The patients were randomly divided into a study group and a control group with 25 cases in each group. The study group received the treatment of cefoperazone sodium and the control group received levofloxacin treatment. The effective rate of treatment in urinary tract infection and the occurrence of adverse reactions of the two groups were compared. Results： The effective rate of the study group and the control group were 100% and 88% respectively. The difference is statistically significant （P<0.05）. One case of diarrhea associated antibiotic occurred in the study group， while 2 cases of skin rash and 1 case of nausea occurred in the control group. The incidence rate of adverse reactions in two groups were respectively 4% and 12% and the difference was statistically significant （P<0.05）. Conclusion： Compared with levofloxacin， curative effect of cefoperazone sodium in the treatment of senile urinary tract infection n elder patients is more positive and cefoperazone sodium is more safe in clinical use.

[key words]Elder； Urinary tract infection； Levofloxacin； Cefoperazone sodium

尿路感染的临床症状主要为尿频、尿急、尿痛或肾区叩痛，以变形杆菌、产气杆菌、克雷白肺炎杆菌等革兰阴性菌多见。近幾年抗生素的滥用，导致耐药菌株日益增多，给临床的抗生素选择带来了极大的困难。因此本次研究拟收集2012年至今我院诊断为尿路感染的老年患者，探讨左氧氟沙星和头孢哌酮钠的治疗疗效。

1 资料与方法

1.1 病例选择

收集2012年至今我院诊断为尿路感染的老年患者作为本次研究对象，按随机号码表法分为两组，25例研究组和25例对照组，研究组接受头孢哌酮钠治疗，对照组接受左氧氟沙星治疗。研究组平均年龄（63.1±2.5）岁，男性10人，女性15人；对照组平均年龄（62.9±2.4）岁，男性11人，女性14人；两组人员性别、年龄差异无统计学意义。

1.2 入选标准

年龄大于18周岁，起病24小时内来我院就诊，起病后未服用过其他抗菌药物。

1.3 排除标准

对左氧氟沙星或头孢哌酮过敏者、孕妇及哺乳期妇女。

1.4 治疗方法

1.4.1 研究组 静脉滴注头孢哌酮钠（批准文号：国药准字H20013205，生产厂家：珠海联邦制药股份有限公司中山分公司）。……