妊娠合并甲减患者78例临床诊治观察
2015-10-21王毅
王毅
摘要: 目的: 分析妊娠合并甲减患者临床诊疗方式及疗效。方法: 选取我院78例妊娠合并甲减患者(观察组)与甲状腺功能正常孕妇78例(对照组),观察组及时诊断并积极治疗,对比2组妊娠结局。结果: 观察组剖宫产51例(65.4%),高于对照组的9例(36.0%),P<0.05;观察组各类妊娠合并症发生率均高于对照组(P<0.05);对照组新生儿健康状况良好、平均体重(3662±13.5)g,观察组新生儿中甲状腺功能减退4例、低体重儿2例,平均体重(3046±26)g,治疗组新生儿先天甲减等发生率高于对照组,体重小于对照组(P<0.05)。结论: 妊娠合并甲减患者更易出现各类妊娠合并症,及时诊断和积极治疗有助于改善妊娠结局、避免先天性甲低新生儿的出现。
关键词: 妊娠;甲减;诊断;治疗
Abstract: Objective to analyze the pregnancy merge Hypothyroidism clinical diagnosis and treatment methods and curative effect. Methods select our hospital 78 cases of pregnancy with Hypothyroidism (observation group) and thyroid function in patients with 78 cases of normal pregnant women (control group), the observation group timely diagnosis and active treatment, compared two groups pregnancy outcome. Results observation group were 51 cases (65.4%), 9 cases (36.0%) is higher than the control group, P < 0.05; All kinds of pregnancy complications incidence of observation group were higher than that of control group (P < 0.05); Control group in good health, average weight (3662 + / - 13.5) g, observation group of neonatal hypothyroidism in 4 cases, malformation in 2 cases, the average weight (3046+ /-26) g, the treatment group birth Hypothyroidism incidence is higher than the control group, the weight is less than the control group (P < 0.05). Conclusion pregnancy with Hypothyroidism patients prone to all kinds of pregnancy complications, timely diagnosis and aggressive treatment is helpful to improve the pregnancy outcome and avoid the occurrence of low neonatal congenital armour.
Keywords: pregnancy; Hypothyroidism ; Diagnosis; treatment
甲減即甲状腺功能减退,妊娠妇女发生甲减的几率较高,此类孕妇易流产、胎儿发育不良或诱发产科并发症,不及时筛查和治疗会严重威胁母婴健康[1]。本研究为寻求科学有效的妊娠合并甲减诊疗方案,对比了妊娠合并甲减患者于健康孕妇妊娠结局,分析了妊娠合并甲减孕妇积极治疗效果,现报道如下。
1 一般资料与方法
1.1 一般资料
选取我院78例妊娠合并甲减患者(观察组),年龄22~36岁,平均年龄(28.8±2.4)岁;孕周33~42周,平均孕周(38.2±0.3)周;初产妇46例,经产妇32例,亚临床甲状腺功能减退14例、自身免疫性甲状腺炎13例、临床甲状腺功能减退51例。另选甲状腺功能正常孕妇78例(对照组),年龄22~38岁,平均年龄(29.3±2.2)岁;孕周34~41周,平均孕周(38.6±0.7)周;初产妇42例,经产妇36例。2组患者基础资料和妊娠状况对比无统计学差异,P>0.05。
1.2 方法
诊断:规范采集静脉血标本,通过放射免疫技术测定分析血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)水平,检查发现TT3、TT4、FT3、FT4指标水平下降,且TSH水平上升;血清TSH水平高于5.6μIU/mL,FT3食品低于2.8pmol/L、FT4水平低于12.0pmol/L,TT3水平低于1.3nmol/L、TT4水平低于66.0nmol/L,即诊断为妊娠合并甲减。
治疗:观察组确诊后,予以左旋甲状腺素口服治疗。孕早期及中期、晚期均要遵医嘱接受FT3、FT4及TSH等指标检测分析,了解病情变化。期……
