简清勇

[摘要] 目的 探讨布地奈德雾化吸入联合阿奇霉素治疗儿童支原体肺炎的临床效果。 方法 选取2013年2月～2015年2月我院收治120例支原体肺炎患儿，将其随机分为观察组和对照组，对照组采用阿奇霉素治疗，观察组在对照组治疗基础上加用布地奈德雾化吸入治疗，比较两组患儿治疗效果及对血清IgE、IL-3、IL-4水平的影响。 结果 观察组治疗总有效率为98.33%，明显高于对照组的83.33%，两组比较差异有统计学意义（P<0.05）；治疗后观察组患儿血清IgE、IL-3、IL-4水平均低于对照组，两组间各值比较差异有统计学意义（P<0.05）。 结论 布地奈德雾化吸入佐治儿童支原体肺炎可降低血清IgE、IL-3、IL-4水平，提高治疗效果，值得临床推广应用。

[关键词] 布地奈德；支原体肺炎；儿童

[中图分类号] R974 [文献标识码] A [文章编号] 1674-4721（2015）09（c）-0085-03

Clinical observation of budesonide atomizing inhalation combined with azithromycin in the treatment of children with Mycoplasma pneumonia

JIAN Qing-yong

Department of Internal Paediatrics，People′s Hospital of Xinyu City in Jiangxi Province，Xinyu 338000，China

[Abstract] Objective To explore the influence of budesonide aerosol inhalation treating Mycoplasma pneumonia in children on serum IgE，IL-3 and IL-4 level. Methods 120 children with Mycoplasma pneumonia treated in our hospital from February 2013 to February 2015 were selected and divided into two groups randomly，the observation group and the control group.The control group was treated with azithromycin，based on which the control group was treated with budesonide aerosol inhalation.The treatment effect between two groups and the influence on serum IgE，IL-3 and IL-4 level was compared respectively. Results The total effective rate of observation group was 98.33%，and that of control group was 83.33%，with statistical difference （P<0.05）.After treatment，the serum IgE，IL-3 and IL-4 level of the observation group was lower than that of control group respectively，with statistical difference（P<0.05）. Conclusion Budesonide aerosol inhalation treating Mycoplasma pneumonia in children can reduce serum IgE，IL-3 and IL-4 level，and improve the treatment effect，which is worthy of clinical promotion and application.

[Key words] Budesonide；Mycoplasma pneumonia；Children

儿童支原体肺炎为儿科常见疾病之一，是由肺炎支原体感染引起的患儿呼吸系统疾病，临床发病率约为19%[1]。感染支原体肺炎后患儿机体发生炎症反应，体内免疫调节因子增多，血清IgE、IL-3、IL-4水平影响较明显[2]。临床常通过检测血清IgE、IL-3、IL-4水平判定支原体肺炎的发生与治疗[3]。本文探究布地奈德雾化吸入佐治儿童支原体肺炎疗效及对血清IgE、IL-3、IL-4水平的影响效果。

1 资料与方法

1.1 一般资料

选取2013年2月～2015年2月我院收治120例支原体肺炎患儿为研究对象，根据患儿入组顺序进行编号，采用计算机随机抽签分组方法将其分为观察组和对照组，每组60例。观察组中男32例，女28例，年龄4个月～14岁，平均（6.2±1.7）岁；对照组中男34例，女26例，年龄5个月～13岁，平均（6.0±1.6）岁。两组患儿在性别、年龄等一般临床资料上比较，差异无统计学意义（P>0.05），具有可比性。所有患儿家属均自愿参加本次研究，并签署知情同意书。

1.2 纳入与排除标准[4]

所有患儿入院后根据病史、临床症状，结合血常规、支原体抗体等相关辅助检查均明确诊断为支原体肺炎；……