常琪

[摘要] 目的 探究对急性缺血性脑血管病患者行氯吡格雷与吲哚布芬片疗法的临床效果。方法 整群选取2013年5月—2015年5月该院接收的急性缺血性脑血管病患者76例为该研究对象，依据分层法将其划分为对照组、实验组，分别行氯吡格雷治疗、吲哚布芬片治疗，对比疗效。结果 实验组行吲哚布芬片治疗后有效率（97.37% vs 94.74%）较对照组无明显改变，且血小板聚集率（0.5浓度诱导：（23.90±3.55） vs （23.28±2.02）；1.0浓度诱导：（47.35±3.34） vs （47.01±2.25））较对照组无显著性变化，差异无统计学意义（P>0.05）。结论 对急性缺血性脑血管病患者行吲哚布芬片或氯吡格雷治疗，均可发挥抗血小板聚集作用，减少血小板聚集率，临床须引起足够重视。

[关键词] 急性缺血性脑血管病；氯吡格雷；吲哚布芬片；临床效果

[中图分类号] R59 [文献标识码] A [文章编号] 1674-0742（2015）08（c）-0110-02

Clinical Comparison of Indobufen Tablets and Clopidogrel in the Treatment of Acute Ischemic Cerebrovascular Disease

CHANG Qi

Department of Internal Medicine-Neurology， Anyang People's Hospital， Anyang， Henan Province， 455000 China

[Abstract] Objective To explore the clinical effect of indobufen tablets and clopidogrel in the treatment of patients with acute ischemic cerebrovascular disease. Methods 76 patients with acute ischemic cerebrovascular disease admitted into the hospital from May 2013 to May 2015 were selected as the research object and were divided into the control group and the experimental group according to stratification method. And the two groups were respectively treated with clopidogrel and indobufen tablets. The curative effects were compared. Results The efficiency of the experimental group after the given treatment was （97.37% vs 94.74%）. Compared with that of the control group， there were no obvious changes. And the rate of platelet aggregation （0.5 concentration induction： （23.90±355） vs （23.28±2.02）； 1.0 concentration induction： （47.35±3.34） vs. （47.01±2.25） did not change significantly compared with those of the control group and the difference was not significant （P > 0.05）. Conclusion To adopt indobufen tablets or clopidogrel in the treatment of acute ischemic cerebrovascular disease both can inhibit platelet aggregation and reduce the rate of platelet aggregation， so enough clinical attention should be paid.

[Key words] Acute ischemic cerebrovascular disease； Clopidogrel； Indobufen tablets； Clinical effect

缺血性脑血管病为临床多发病，主要是指多条（或一条）脑血管缺血所致该供血区显现脑功能障碍，呈局灶性，病因相对复杂，往往存在糖尿病、高血压等基础性病变，具有较高的致残率及致死率。目前，针对该病治疗而言，临床上多以抗血小板凝集为主要原则及目的，常用药物包括氯吡格雷、阿司匹林及吲哚布芬片等，其中氯吡格雷、吲哚布芬片在缺血性脑血管病治疗中的优势较为独特，对降低血小板聚集率、改善患者预后具有十分重要的应用意义。为了深入探究对急性缺血性脑血管病患者行氯吡格雷与吲哚布芬片疗法的临床效果，本文主要对该院76例急性缺血性脑血管病患者行对照研究，现报道如下。