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子宫内膜异位症合并不孕妇女内分泌临床研究

2015-08-29杨羞花

中外医疗 2015年11期
关键词:临床研究

杨羞花

[摘要]目的 探析子宫内膜异位症合并不孕女方内分泌激素水平及自身抗体免疫情况。方法 选取该院2012年1月—2014年12月收治的120例子宫内膜异位症(EMS)及不孕症患者,并根据患者疾病类型分为单纯不孕组(A组)38例、单纯子宫内膜异位症组(B组)42例及子宫内膜异位合并不孕症组(AB组)40例,同时选取健康体检者40例,作为对照组,采取化学免疫荧光法测定各组患者血清中的T(睾酮)、INS(胰岛素)、E2(雌二醇)、PRL(泌乳素)、FSH(卵泡刺激素)及LH(黄体生成素)水平,并采取ELISA酶联合免疫法进行测定各组患者AOAb(抗卵巢抗体)、ACAb(抗心磷脂抗体)、ASAb(抗精子抗体)、HCGAb(抗绒毛促性腺激素抗体)及EMAb(抗子宫内膜抗体)阳性情况。结果 AB组患者的PRL、INS、T、E2水平均明显高于A组和B组,差异有统计学意义(P<0.05),FSH及LH水平3组差异无统计学意义(P>0.05),A组和对照组患者的血清PRL水平显著低于B组,差异有统计学意义(P<0.05),其他各指标差异无统计学意义(P>0.05);AB组的抗体总阳性率明显高于其他3组,差异有统计学意义(P<0.05),A组和B组之间抗体阳性率差异无统计学意义(P>0.05)。结论 引起患者发生子宫内膜异位症不孕症的主要因素有可能是子宫内膜异位免疫失衡引起的T、E2、和PRL内分泌异常,通过对其内分泌水平进行分析研究,旨在为临床提供可靠依据。

[关键词]子宫内膜异位症;不孕症;内分泌;临床研究

[中图分类号]R711.71 [文献标识码]A [文章编号]1674-0742(2015)04(b)-0019-02

The Clinical Study on Endometriosis combined with infertile women endocrine

YANG XiuHua

Guilin Maternal and Child Health Care, Guilin, Guangxi Province, 541001 China

[Abstract] objective to explore endometriosis merger infertility women autoantibodies immune and endocrine hormone levels.Methods selected our hospital from January 2012 to December 2014 120 examples of intrauterine membrane endometriosis (EMS) and infertility patients, and depending on the type of disease in patients, divided into pure with infertility group (group A), 38 cases, pure endometriosis group (group B) merger of 42 cases of endometriosis and infertility group 40 cases (AB), and 40 cases of healthy check-up, as control group, took chemical immunofluorescence method for determination of T (testosterone) in groups of patients serum, INS (insulin) and E2 (estradiol), PRL (prolactin), FSH (follicle-stimulating hormone) and LH (luteinizing hormone) level, and took with ELISA enzyme immune method for determination of each group were AOAb (ovarian) antibodies, ACAb (anti cardiolipin antibody), ASAb (antisperm antibody), HCGAb (resistance to fluff gonadotropin) antibodies and EMAb (resistance to endometrial antibody) positive. Results patients of group AB with PRL, INS, T, E2 levels were significantly higher than that of group A and group B, the difference was statistically significant(P< 0.05), FSH and LH level difference three groups was not significant(P>0.05), the difference was not statistically significance, group A and the control group in patients with serum PRL level was significantly lower than that of group B(P< 0.05), other indicators has no marked difference(P > 0.05); Antibody total positive rate of group AB was obviously higher than that of the other three groups(P < 0.05), the rate of positive of antibody of differences between group A and group B was not statistically significant(P > 0.05). Conclusion the main factors that cause endometriosis patients with infertility may be due to a endometriosis immune imbalance of T, E2, PRL and endocrine abnormalities, through the analysis of the level of endocrine research, which aims to provide a reliable basis for clinical.

[key words] Endometriosis; Infertility; Endocrine; Clinical study

EMS(子宫内膜异位症)是育龄女性较为常见的疾病之一,能够引发不孕症。目前,随着该病的发生了不断上升,致使该病合并不孕症的发生率也随之上升[1]。虽然EMS合并不孕症在临床上较为常见,但是对其发病机制目前尚不十分明确。根据相关的文献研究表明,患者自身抗体免疫阳性能够致使生殖激素发生紊乱,进而引发不孕症[2]。……

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