杨晓蕾+张钦婷+边振+孙权+葛杰

[摘要] 目的 观察口服美托洛尔联合依那普利治疗中青年人原发性高血压的临床效果。 方法 选取2012年3月～2013年3月山东省中医药研究院附属医院门诊原发性高血压中青年患者180例，随机分为两组，实验组90例患者口服依那普利5 mg，2次/d，美托洛尔25 mg，2次/d；对照组90例患者口服依那普利5 mg，2次/d。比较两组患者的临床疗效。 结果 实验组头痛、头昏、呕吐发生状况明显少于对照组（P＜0.05）。两组降压疗效比较，实验组总有效率为95.6%，对照组总有效率85.6%，实验组降压效果明显优于对照组。 结论 依那普利联合美托洛尔治疗高血压比单独应用依那普利的治疗效果更佳。

[关键词] 依那普利；美托洛尔；高血压

[中图分类号] R544.1[文献标识码] A[文章编号] 1674-4721（2014）03（c）-0073-03

Effect observation of metoprolol combined with enalaprilat treatment essential hypertension in young and middle-aged patients

YANG Xiao-lei1 ZHANG Qin-ting2 BIAN Zhen3 SUN Quan4 GE Jie1▲

1.Department of Preventive Medicine,Qiqihar Medical School of Public Health,Qiqihar 161006,China;2.Beijing Xicheng District Health Bureau Niujie Community Health Centers,Beijing 100053,China;3.Department of Medicine,Shandong Province Hospital of Traditional Chinese Medicine Institute,Jinan 250014,China;4.Department of Anatomy,Qiqihar Medical College of Basic Medical,Qiqihar 161006,China

[Abstract] Objective To observe the clinical effect of metoprolol combined with enalaprilat treatment essential hypertension in young and middle-aged patients. Methods 180 young and middle-aged patients with essential hypertension in outpatient service of Shandong Province Hospital of Traditional Chinese Medicine Institute from March 2012 to March 2013,they were randomly divided into two groups,the experimental group patients (n=90) with oral enalaprilat 5 mg,twice per day,metoprolol1 25 mg and twice per day,the control group patients (n=90) with oral enalapril 5 mg and twice per day.The clinical effect of two groups were compared. Results The headache,dizziness,vomiting occurred in experimental group were significantly less than those of the control group (P<0.05).Antihypertensive effects in the two groups,total effective rate in experimental group was 95.6%,total effective rate in control group was 85.6%,the antihypertensive effect in experimental group was better than that of the control group. Conclusion The effect of enalaprilat combined with metoprolol treatment hypertension is better than single application of enalaprilat.

[Key words] Enalapril;Metoprolol;Hypertension

原发性高血压是最常见的心血管疾病之一，是遗传与环境因素长期相互作用的结果，老年人群的发病率更高[1]。随着生活节奏的变快，生活压力的增加以及周围环境的变化，使得此病在中青年人中的发病率越来越高。原发性高血压合并心力衰竭不仅病死率高，而且预后差，严重影响患者的生活质量[2]。在临床治疗过程中，以既能平稳降压又能消除心力衰竭主要临床症状为主要目的[3]。然而，人群高血压的知晓率、治疗率和控制率却很低，分别为30%、25%和6%，这意味着我国多数高血压患者不知道自己患病，3/4的高血压患者没有进行正规治疗；大多数高血压患者的血压未达标。控制血压，选择合理的降压药物十分重要。本研究主要对高血压患者联合使用依那普利与美托洛尔进行治疗，观察其疗效，并与单独使用依那普利治疗的高血压患者作对比，现报道如下。……