张志雄+许向前+何咏+邓列华

[摘要] 目的 观察0.05%丙酸氟替卡松乳膏治疗儿童湿疹的近期临床效果。 方法 将80例儿童湿疹患者随机分为治疗组（外用0.05%丙酸氟替卡松乳膏，1次/d）；对照组（外用0.1%糠酸莫米松乳膏，1次/d）；两组各40例，用药疗程均为2周。观察两组患者用药后1、2周的临床疗效。 结果 用药后1周治疗组和对照组总有效率分别为60.0%、37.5%，两组比较差异有统计学意义（P<0.05）。用药后2周治疗组和对照组总有效率分别为82.5%、52.5%，两组比较差异有统计学意义（P<0.05）。两组患者用药后均无严重不良反应发生。 结论 外用0.05%丙酸氟替卡松乳膏比外用0.1%糠酸莫米松乳膏2周治疗儿童湿疹的疗效佳、安全性好，是临床治疗儿童湿疹疗效较好的方法之一。

[关键词] 儿童湿疹；0.05%丙酸氟替卡松乳膏；临床疗效

[中图分类号] R758.23[文献标识码] A[文章编号] 1674-4721（2014）03（c）-0068-03

Recent clinical effect observation of 0.05% fluticasone propionate cream in the treatment of child eczema

ZHANG Zhi-xiong XU Xiang-qian HE Yong DENG Lie-hua▲

Department of Dermatology,the First Affiliated Hospital of Jinan University, Guangzhou 510630,China

[Abstract] Objective To observe the recent clinical effect of 0.05% fluticasone propionate cream in the treatment of child eczema. Methods 80 child patients with eczema were evenly divided into treatment group (0.05% fluticasone propionate cream for external use,one per day) and control group (0.1% mometasone furoate cream for external use,one per day) in random.The course of treatment was both 2 weeks and the clinical effects one and two weeks after medication in both groups were observed. Results One week after therapy,the total effective rate in the treatment group and control group was 60.0% and 37.5% with significant difference (P<0.05).After two weeks,the total effective rate was 82.5% and 52.5% in the treatment group and control group respectively,which displayed a statistical difference (P<0.05).There was no serious adverse reaction occurred in both groups after medication. Conclusion After two-week treatment of child eczema,external use of 0.05% fluticasone propionate cream can obtain a more favorable curative effect and better safety in comparison with 0.1% mometasone furoate cream,which is a preferable approach to treat child eczema in clinic.

[Key words] Child eczema;0.05% fluticasone propionate cream;Clinical effect

湿疹是一种常见的过敏性炎症性皮肤病，以皮疹多样性、对称分布、剧烈瘙痒、反复发作、易演变成慢性为特征，可发生于任何年龄、任何部位、任何季节，在皮肤科常见病中占有很大比例[1]。儿童湿疹是湿疹类型中的一种，与成人湿疹本质上没有区别，但儿童湿疹包括婴儿湿疹和幼儿湿疹的疹型与成人湿疹的疹型不完全相同。在儿童湿疹的治疗中，外用糖皮质激素较为常见，且种类繁多，效果参差不齐，由于儿童特殊的生理结构和发育状态，选择一种既高效又安全的药物特别重要。本研究对2012年6月～2013年8月收治的40例儿童湿疹患者外用0.05%丙酸氟替卡松乳膏治疗，疗程为2周，取得较好疗效，现报道如下。……