[摘要] 目的 观察畲药地菍鼻腔冲洗治疗儿童慢性鼻窦炎的临床疗效。方法 选取2022年1至6月丽水市中医院门诊收治的63例慢性鼻窦炎患儿作为研究对象，采用随机数字表法分为对照组（n=33）与治疗组（n=30）。对照组采用2.3%高渗盐水鼻腔冲洗，治疗组采用畲药地菍鼻腔冲洗。比较两组患儿的临床疗效、鼻窦CT Lund-Mackay评分，鼻腔冲洗液白细胞介素（interleukin，IL）-6、IL-8、肿瘤坏死因子（tumor necrosis factor，TNF）-α水平及安全性。结果 经过3个月的治疗，治疗组患儿的临床总有效率高于对照组（Plt;0.05）。治疗后两组患儿的鼻窦CT Lund-Mackay评分均下降，治疗组患儿优于对照组（Plt;0.05）。两组患儿的鼻腔冲洗液中IL-6、IL-8及TNF-α水平均显著降低（Plt;0.05）。 结论 地菍鼻腔冲洗可有效治疗儿童慢性鼻窦炎，临床总有效率、IL-6、IL-8炎症因子及鼻窦CT Lund-Mackay评分改善情况优于2.3%高渗盐水，且安全性良好。

[关键词] 地菍；鼻腔冲洗；慢性鼻窦炎；临床研究

[中图分类号] R729""""" [文献标识码] A""""" [DOI] 10.3969/j.issn.1673-9701.2025.20.011

Clinical study on the treatment of chronic sinusitis in children by nasal irrigation with She Ethnic Medicine Melastoma dodecandrum

WU Jun^1，2， LEI Houxing^1，2， ZHANG Xiaoqin^2，3， ZHANG Yixing^1，2

1.Department of Pediatrics， Lishui Hospital of Traditional Chinese Medicine，Lishui 323000， Zhejiang， China; 2.Key Laboratory of She Medicine， Lishui 323000， Zhejiang， China; 3.Pharmaceutical Research Center of Lishui Hospital of Traditional Chinese Medicine，Lishui 323000， Zhejiang， China

[Abstract] Objective To observe the clinical efficacy of Melastoma dodecandrum （MD） nasal irrigation in the treatment of chronic sinusitis in children. Methods A total of 63 children with chronic sinusitis， treated at Lishui Hospital of Traditional Chinese Medicine from January to June 2022 were selected as the study subjects. They were divided into control group （n=33） and treatment group （n=30） by a random number table method. The control group received nasal irrigation with 2.3% hypertonic saline， while the treatment group received nasal irrigation with MD. The clinical efficacy， Lund-Mackay score of sinus CT， levels of interleukin （IL）-6， IL-8， and tumor necrosis factor （TNF）-α in the nasal irrigation fluid， and safety were compared between two groups. Results After 3 months of treatment， the effective rate of treatment group was higher than that of control group （Plt;0.05）. After treatment， the CT Lund-Mackay scores for both groups of children decreased， with treatment group showing a better improvement （Plt;0.05）. Levels of IL-6， IL-8， and TNF-α in the nasal irrigation fluid of both groups were significantly reduced （Plt;0.05）. Conclusion MD nasal irrigation can effectively treat chronic sinusitis in children， the clinical total effective rate， IL-6， IL-8 inflammatory factors and sinus CT Lund-Mackay score improvement are better than 2.3% hypertonic physiological seawater， and safety is good.

[Key words] Melastoma dodecandrum; Nasal irrigation; Chronic sinusitis; Clinical research

慢性鼻–鼻窦炎（chronic rhinosinusitis，CRS）是指鼻窦及鼻腔的慢性炎症性疾病，病程gt;12周，以鼻塞、黏性或黏脓性鼻涕、咳嗽为主要特点^[1-2]。儿童发生CRS的概率为0.5%～5.0%，发病年龄3～8岁，且发病率逐年增加，CRS常伴随腺样体肥大，出现打鼾、张口呼吸等症状，是造成儿童慢性咳嗽的主要原因，严重影响儿童身体健康^[3-6]。CRS的发病与鼻腔解剖结构异常、细菌和病毒及真菌感染、免疫缺陷、纤毛运动障碍等多种因素有关^[7]。目前鼻用激素和鼻腔冲洗成为一线用药，而以物理治疗为主的鼻腔冲洗逐渐成为儿童CRS的有效方式^[8]。本研究探讨畲药地菍通过鼻腔冲洗方式治疗儿童CRS的临床疗效、安全性及炎症因子水平。……