Effect of Gastrointestinal Pacemaker Combined with Zusanli Acupoint Injection on Senile Functional Constipation/CHEN Li， CHEN Qin.//Medical Innovation of China，2025，22（18）： 049-053

[Abstract] Objective：To explore the effects of gastrointestinal pacemaker combined with Zusanli acupoint injection on gastrointestinal hormone levelsandconstipation condition in elderlypatients with functional constipation.Method：A totalof96 elderly patients with functional constipation who visited HubeiProvincial Hospitalof Integrated Chineseand Western Medicine from February2022 to March2024 weredivided into the pacing group （n=48） and the combined group （ n =48）according to the random number table method.The pacing group was treated with gastrointestinal pacemaker，and the combined group was treated with gastrointestinal pacemaker combined with Zusanli acupoint injection. The therapeutic effect，constipation condition，anorectal dynamic indicators，gastrointestinal hormone levels and TCM syndromes integrations of the two groups were compared.Result： The total effectiverate of treatment in the combined group was higher than that in the pacing group Plt;0.05） .After the treatment，the frequencyof defecation in both groups increased，and that in the combined" group was more than that in the pacing group，the defecation diffculty scores，incomplete defecation scores and patient assessment of constipation-symptom （PAC-SYM） scores in both groups decreased，and those in the combined group were lower than those in the pacing group （Plt;0.05） .After the treatment， the rectal resting pressure and anal canal resting pressure in both groups increased，and those inthe combined group were higher than those in the pacing group （ P lt;0.05）.After the treatment，the levels of gastrin，motilin and vasoactive peptide in both groups increased，and those in the the combined group were higher than those in the pacing group （ P lt;0.05）. After the treatment，the scores of abdominal bloating，defecation discomfort，belching and chest and hypochondrium fullness and distress in both groups decreased，and those in the combined group were lower than those in the pacing group （ P lt;0.05）.Conclusion： Gastrointestinal pacemaker combined with Zusanli acupoint injection can improve the constipation symptoms and anorectal dynamics of elderly patients with functionalconstipation，and increase the levels of gastrointestinal hormone.

[Keywords] Senile functional constipation Gastrointestinal pacemaker Zusanli Acupoint injection Gastrointestinal hormone

First-author'saddress：DepartmentofRehabilitation，HubeiProvincial Hospitalof Integrated hinese and Western Medicine，Wuhan 43oo15， China doi：10.3969/j.issn.1674-4985.2025.18.012

功能性便秘是一种缺乏器质性病因，没有结构异常或代谢障碍，且排除肠易激综合征的慢性便秘，其主要症状为大便干结、排便困难及排便频次减少，是老年人常见的消化系统问题之一[-2]。由于功能性便秘患者常伴有胄肠激素紊乱和肛肠动力学的改变，单纯缓泻治疗对其改善效果不佳。胃肠起搏仪作为一种新兴的物理治疗方法，其工作原理基于胃肠起搏点的电活动可被外加电流刺激所驱动，促使紊乱的胃肠电活动产生跟随效应，以恢复正常节律[。由于不同患者对胃肠起搏仪的治疗反应存在个体差异，可能无法达到预期效果。中医理论认为，老年功能性便秘多因津液亏虚、气血不足所致，治疗应以益气养阴、健脾和胃为基本原则[4。足三里作为中医临床应用极为广泛的穴位之一，具有健脾和胃、通经活络的功效，足三里穴位注射通过针刺和药物的双重作用，刺激穴位，调节内脏活动，促进胃肠道蠕动，达到治疗便秘的目的[5。由于足三里穴位注射联合胃肠起搏仪对老年功能性便秘患者胃肠激素水平和肛肠动力学的研究较少，因此，本研究旨在探讨胃肠起搏仪联合足三里穴位注射对老年功能性便秘患者胃肠激素水平、便秘情况的影响。

1资料与方法

1.1一般资料

选择2022年2月一2024年3月于湖北省中西医结合医院就诊的96例老年功能性便秘患者。纳入标准：（1）西医符合罗马V标准中功能性便秘诊断（症状出现至少半年，且近12周出现……