Study on the Changes in Levels of Thyroid Hormones inPregnant Women/GUO Qunguang.//Medical nnovation of China，2025，22（18）：122-125

[Abstract]Objective： To study and analyze the changes in levels of thyroid hormones in pregnant women. Method： A retrospective analysis was conducted on 8O pregnant women admitted to Ji'an Maternal and Child HealthHospital （Children's Hospital） from January2O22 to January 2O24，allof whom underwentthyroid hormone level tests.Meanwhile，5O healthy women who were not pregnant were selected as the non-pregnancy control group.The levels of free T₃ ？ FI₃^′） ， free T₄（FT₄） ，and thyroid stimulating hormone （TSH） in different research subjects were compared.Result：Among the8O pregnant women，there were 26cases inthe first trimester，33 cases inthe second trimesterand 21 casesin last trimester.The levelsof FI₃^′ and FI₄^⋅ in the first trimester group were higher than those in the non-pregnancycontrol group，while those in the second trimester group were lowerthanthose in the first trimester group，and those in the third trimester group were lower than those in the second trimester group， the differences were statistically significant （ Plt;0.05 ）.The TSH level in the first trimester group waslower than that in the non-pregnancycontrol group，the TSH level in the second trimester group was higher than that in the first trimester group，and the TSH level in the third trimester group was higher than thatin thesecond trimester group， thedifferenceswereall statistically significant （ P lt;0.05）.Conclusion：There iscertainregularityin the changes of thyroid hormones inpregnant women，which isworthyofreferenceforclinicalworkersandmedical researchers.

[Keywords]PregnancyperiodFreeTFree T₄ Thyroid stimulating hormone Change trend

First-author'saddress： Clinical Laboratory，Ji'anMaternal and Child Health Hospital （Children's Iospital），Ji'an343000，China

doi：10.3969/j.issn.1674-4985.2025.18.028

妊娠期妇女的甲状腺激素水平是重要的评估指标，因为它直接关系到母婴的健康l。有研究指出，妊娠期妇女的甲状腺激素水平会随着孕期的不同而有所变化。通常情况下，甲状腺激素水平主要是通过检测促甲状腺激素（TSH）来评估的。随着孕周的增加，其TSH水平存在不同程度的增加[2。妊娠期间，对机体各项指标进行定期的考察和评估是十分重要的。因甲状腺激素水平过高可能导致流产、早产、胎盘早剥、妊娠期高血压等一系列不良后果。同时，还可能影响胎儿的神经系统和骨骼系统发育，导致智力低下、身材矮小等[3-4]。与此同时，甲状腺激素水平偏低同样对胎儿的发育产生不利影响。母体甲状腺激素不足时，胎儿的神经系统和智力发育可能受到严重损害，甚至导致呆小症[5。游离 T₃ （ FT₃ ）和游离 T₄ （ FT₄ ）在妊娠期的应用价值主要体现在评估孕妇的甲状腺功能以及监测胎儿的发育状况上。 FT₃ 是甲状腺激素中活性最强的一种，对胎儿的大脑发育和神经系统功能有重要作用。 FT₄ 对胎儿的生长和发育有重要影响。其水平能反映甲状腺分泌甲状腺激素的总量。随着医疗技术的进步以及人民群众对医学知识储备的提升，在孕期检测甲状腺激素水平已受到越来越多人民的认可。基于此，本研究采用回顾性分析探究妊娠期妇女甲状腺激素水平的变化规律，现报道如下。

1资料与方法

1.1一般资料

回顾性分析2022年1月—2024年1月收治的80例妊娠期女性。（1）纳入标准： ① 妊娠期女性；……