[摘要] 目的 探讨近20年中医药治疗多发性骨髓瘤（multiple myeloma，MM）领域的研究现状、热点及未来发展趋势。方法 检索中国知网、万方数据知识服务平台和维普网数据库自2004年1月至2024年4月收录的中医药在MM治疗领域的相关文献，采用NoteExpress软件合并去重，使用CiteSpace6.3.R1软件对纳入文献的作者、研究机构和关键词等进行可视化分析。结果 共纳入420篇文献，发文量总体呈上升趋势；发文量最多的作者是周郁鸿，核心作者共25位；发文量最高的机构是山东中医药大学附属医院；共得到277个关键词，通过对高频关键词归纳可见目前的研究热点聚焦于发病机制、化疗药物、不良反应、中医辨证论治等方面。结论 中医药治疗MM的研究热度不断上升，研究热点为中药单体有效成分、名医经验、相关并发症的治疗及中西医联合应用，机制通路及中医特色疗法改善患者的生活质量是未来的研究趋势。

[关键词] 多发性骨髓瘤；中医中药；可视化分析

[中图分类号] R733.3" """"[文献标识码] A """""[DOI] 10.3969/j.issn.1673-9701.2025.19.013

Visual analysis of traditional Chinese medicine in the treatment of multiple myeloma based on CiteSpace

LIU Xinran¹， SUN Changyong²

1.College of Traditional Chinese Medicine， Hebei North University， Zhangjiakou 075000， Heibei， China; 2.Department of Transplantation， Langfang Traditional Chinese Medicine Hospital， Langfang 065000， Heibei， China

[Abstract] Objective To explore the research status， hotspots and future development trends of traditional Chinese medicine in the field of multiple myeloma （MM） treatment in the past 20 years. Methods Retrieve the relevant literatures of traditional Chinese medicine in the field of MM treatment included in CNKI， Wanfang Data Knowledge Service Platform and VIP database from January 2004 to April 2024. The NoteExpress software was used for merging and deduplication， and the CiteSpace6.3.R1 software was used for visual analysis of the authors， research institutions and key words of the included literatures. Results A total of 420 literatures were included， and the overall number of published articles showed an upward trend. The author with the highest number of articles was Zhou Yuhong， with a total of 25 core authors. The institution with the highest number of published articles was the Affiliated Hospital of Shandong University of Traditional Chinese Medicine. A total of 277 key words were obtained. Through the induction of high-frequency key words， it could be seen that the current research hotspots focus on aspects such as the pathogenesis， chemotherapy drugs， adverse reactions， and treatment based on syndrome differentiation in traditional Chinese medicine. Conclusion The research interest in the Chinese medicine treatment of MM is increasing. The research topics currently attracting the most attention are the single active ingredient of Chinese medicine， the experience of renowned medical practitioners， the treatment of associated complications， and the combined use of Chinese and Western medicines. The research focus in the future will be on the mechanism pathway and the Chinese medicine characteristic therapy to enhance the quality of life of patients.

[Key words] Multiple myeloma; Chinese herbal medicine; Visual analysis

多发性骨髓瘤（multiple myeloma，MM）是一种克隆浆细胞异常增殖的恶性血液病。多见于中老年人，其特点是单克隆免疫球蛋白分泌异常增多，临床表现以“CRAB”症状[血钙增高（calcium elevation）、肾功能损害（renal insufficiency）、贫血（anemia）、骨病（bone disease）]及继发性淀粉样变为主^[1]。中医学将MM归于“腰痛”“骨痹”“骨蚀”“血证”“虚劳”等范畴^[2]。《素问·长刺节论》《圣济总录》和《诸病源候论》等经典著作中均有对MM病名及病因病机的描述记载，表明中医学在诊治MM领域已有悠久历史及丰富的理论认识^[3]。CiteSpace软件是一款信息可视化软件，其制作的知识图谱可用于揭示科学知识结构的发展现状乃至未来的发展趋势^[4]。……