沈勤 王千 孙炳霞

【摘要】 目的：探究將维生素D、布地奈德福莫特罗联合运用于支气管哮喘患儿治疗中对外周血T淋巴细胞亚群及肺功能的影响。方法：选取2021年6月—2023年6月宿迁市第一人民医院收治的89例支气管哮喘患儿，并按照治疗方式进行分组，设接受常规单一布地奈德福莫特罗治疗为对照组（n=44），而研究组（n=45）在对照组的基础上予以维生素D辅助治疗。对比两组的临床治疗效果。结果：研究组的哮鸣音消失时间、喘息消失时间、呼吸困难时间均短于对照组（P<0.05）。治疗前，两组CD3+、CD4+及CD8+细胞对比，差异均无统计学意义（P>0.05）；治疗后，研究组的CD3+、CD4+均高于对照组，而CD8+低于对照组（P<0.05）。治疗后，研究组的第1秒用力呼气容积（FEV1）、用力肺活量（FVC）、最大呼气流量（PEF）均高于对照组（P<0.05）。治疗后，研究组治疗总有效率为95.56%，高于对照组的81.82%（字2=4.210，P=0.040）。结论：在小儿支气管哮喘疾病中采用维生素D辅助布地奈德福莫特罗治疗能够缩短哮鸣音、喘息、呼吸困难等症状的消失时间，从而对提升机体的免疫功能和肺功能水平具有显著的成效，在临床疾病治疗过程中具有积极的意义。

【关键词】 维生素D 布地奈德福莫特罗 支气管哮喘 患儿 外周血T淋巴细胞亚群 肺功能

Clinical Application Effect of Vitamin D Assisted Budesonide and Formoterol in the Treatment of Children with Bronchial Asthma/SHEN Qin， WANG Qian， SUN Bingxia. //Medical Innovation of China， 2024， 21（07）： 0-027

[Abstract] Objective： To investigate the effect of the combination of Vitamin D and Budesonide and Formoterol in the treatment of children with bronchial asthma on peripheral blood T lymphocyte subsets and lung function. Method： A total of 89 children with bronchial asthma admitted to Suqian First Hospital from June 2021 to June 2023 were selected， divided into groups according to the differences in treatment methods， and the control group （n=44） was treated with single Budesonide and Formoterol， while the study group （n=45） was treated with Vitamin D adjuvant therapy on the basis of the control group. The clinical treatment effect of the two groups was compared. Result： The disappearance time of wheezing rale， wheezing， and dyspnea time in the study group were shorter than those in the control group （P<0.05）. Before treatment， there were no significant differences between the two groups in CD3+， CD4+ and CD8+ cells （P>0.05）; after treatment， CD3+ and CD4+ in the study group were higher than those in the control group， while CD8+ was lower than that in the control group （P<0.05）. After treatment， while the forced expiratory volume in 1 second （FEV1）， forced vital capacity （FVC） and peak expiratory flow （PEF） in the study group were higher than those in the control group （P<0.05）. After treatment， the total effective rate of treatment in the study group was 95.56%， higher than 81.82% in the control group （字2=4.210， P=0.040）. Conclusion： The use of Vitamin D to assist Budesonide and Formoterol in the treatment of pediatric bronchial asthma can shorten the disappearance time of symptoms such as wheezing rale， wheezing， dyspnea， etc.， which has a significant effect on improving the immune function and lung function of the body， and has positive significance in the treatment of clinical diseases.

[Key words] Vitamin D Budesonide and Formoterol Bronchial asthma Children T lymphocyte  subsets in peripheral blood Lung function

First-author's address： Department of Pediatrics， Suqian First Hospital， Suqian 223800， China

doi：10.3969/j.issn.1674-4985.2024.07.006

支气管哮喘是一种常见的小儿慢性气道炎症疾病，其发病机制尚不明确，临床常见反复发作的胸闷、咳嗽、喘息等症状，而随着疾病的发展，可能出现肺心病、肺气肿、胸廓畸形等多种并发症，对儿童的身心健康造成具有重要意义[1-2]。布地奈德福莫特罗是一种吸入性糖皮质激素，它主要用于治疗支气管哮喘、过敏性支气管哮喘及肺气肿等疾病中，可有效改善患儿的临床症状[3-4]。然而，通过查阅文献，临床发现西医的作用机理较为单一，维生素D与哮喘的发生发展有着紧密的联系，将维生素D应用于治疗过程中，不仅可有效提高治疗效果，而且能改善患儿的肺功能水平，有助于儿童的康复[5-6]。但因临床对于维生素D辅助布地奈德福莫特罗治疗的参考文献较少，故研究通过选取89例支气管哮喘患儿为研究对象，以此为疾病治疗提供参考意义，现报告如下。……