王成有

【摘要】目的：评估对小儿类百日咳综合征患儿予以红霉素、盐酸氨溴索联合治疗的效果。方法：评估对象选择于2021年4月—2022年3月在我院治疗的168例类百日咳综合征患儿，随机分组，84例予以红霉素治疗者归纳到对照组，84例予以红霉素、盐酸氨溴索联合治疗者归纳到试验组，对治疗效果进行评估和比较。结果：两组患儿总有效率分别为96.43%、80.95%，临床疗效，试验组更佳（P<0.05）；症状（痉挛性咳嗽、呼吸困难、肺部啰音）缓解、住院时间，试验组（6.88±1.16）d、（3.01±0.88）d、（5.28±1.15）d、（7.60±2.00）d更短（P<0.05）；两组不良反应发生率分别为9.52%、10.71%，两组不良反应对比，P>0.05。结论：对小儿类百日咳综合征患儿予以红霉素、盐酸氨溴索联合治疗效果突出，可缩短症状缓解时间，可促进患儿康复，建议推广。

【关键词】小儿类百日咳综合征；红霉素；盐酸氨溴索；症状缓解时间

Study on the curative effect of erythromycin combined with ambroxol hydrochloride in the treatment of pertussis syndrome in children and the time of symptom remission

WANG Chengyou

Gansu Medical College Affiliated Hospital， Pingliang， Gansu 744000， China

【Abstract】Objective： To evaluate the effect of combined treatment of erythromycin and ambroxol hydrochloride on children with pertussis syndrome. Methods： A total of 168 children with pertussis syndrome who were treated in our hospital from April 2021 to March 2022 were randomly divided into four groups： 84 patients receiving erythromycin treatment were included in the control group， and 84 patients receiving erythromycin combined with ambroxol hydrochloride were included in the experimental group. The therapeutic effects were evaluated and compared. Results： The total effective rate of the two groups were 96.43% and 80.95%， respectively. The clinical efficacy of the experimental group was better（P<0.05）. （6.88±1.16） d， （3.01±0.88） d， （5.28±1.15） d and （7.60±2.00） d were shorter in the experimental group（P<0.05）. The incidence of ADR in 2 groups was 9.52% and 10.71%， respectively， and the comparison of ADR in 2 groups was P>0.05. Conclusion： The combined treatment of erythromycin and ambroxol hydrochloride for children with pertussis syndrome is effective， which can shorten the time of symptom remission and promote the rehabilitation of children， so it is recommended to popularize.

【Key Words】Pertussis syndrome in children； Erythromycin； Ambroxol hydrochloride； Symptom remission time

類百日咳综合征在临床上为一种常见的儿科疾病，因体征和临床症状相似于百日咳而得名。百日咳作为呼吸系统疾病的一种，致病原因为感染百日咳杆菌，而类百日咳综合征在临床上现阶段发病机制尚不确定，一般认为其相关因素为腺病毒、肺炎支原体、巨细胞病毒感染等[1]。类百日咳综合征症状主要为肺部啰音、呼吸困难、痉挛性咳嗽等，需及时治疗，否则伴随病情进展会导致肺炎发生，使病情和治疗难度均加重，不利于患儿健康和生长发育。在临床上针对该病以药物治疗为主，其中红霉素为常用药物，但是单用效果仍有待提升。为促进疗效提升，保证患儿健康，本研究发现红霉素、盐酸氨溴索联合治疗可促进疗效提升，可使临床症状快速缓解，利于患儿康复。本研究选择于2021年4月—2022年3月在我院治疗的168例类百日咳综合征患儿分组评估，进一步明确联合用药治疗的效果，结果如下。……