孙丕云 陈燕华 冯驭臣 郭会 余璧含 梁艳艳 冯献斌

摘要 目的：探究中醫定向透药治疗仪对癌性疼痛患者疼痛及生命质量的影响。方法：选取2018年1月至2019年12月柳州市中医医院肿瘤科收治的癌性疼痛患者120例作为研究对象，以随机数字表法分为对照组和观察组，每组60例。对照组采取三阶梯止痛疗法治疗，观察组采取中医定向透药治疗仪治疗，观察患者治疗后疼痛分级情况变化、治疗后1 d、治疗后7 d、治疗后14 d、2组患者疼痛评分（视觉模拟评分法，VAS）情况、镇痛起效时间、疼痛缓解持续时间、治疗前后爆发痛发作次数变化、美国东部肿瘤协作组体力状态评分表（ECOG）变化、治疗不良反应情况。结果：治疗前，2组患者疼痛分级情况、爆发痛发作次数、ECOG评分比较，差异无统计学意义（P>0.05），治疗后2组患者疼痛分级情况、爆发痛发作次数、ECOG评分等指标均改善，观察组患者治疗后疼痛分级情况、爆发痛发作次数、ECOG评分等指标优于对照组，差异有统计学意义（P<0.05）;治疗后1 d，2组患者VAS评分比较，差异无统计学意义（P>0.05），治疗后7 d、治疗后14 d，观察组患者VAS评分低于对照组，差异有统计学意义（P<0.05）;与对照组比较，观察组患者镇痛起效时间、疼痛缓解持续时间均更短，差异有统计学意义（P<0.05）;对照组出现1例便秘，1例恶心;观察组出现1例嗜睡，1例便秘，差异无统计学意义（P>0.05）。结论：中医定向透药治疗仪可减轻癌性疼痛患者疼痛，提升其生命质量。

关键词 癌性疼痛;三阶梯止痛疗法;中医定向透药治疗仪;爆发痛发作次数;疼痛分级;疼痛评分;体力状态评分;不良反应

Influence of Traditional Chinese Medicine Directed Penetration Therapy Instrument on Pain and Quality of Life of Cancer Pain Patients

SUN Piyun，CHEN Yanhua，FENG Yuchen，GUO Hui，YU Bihan，LIANG Yanyan，FENG Xianbin

（Department of Oncology，Liuzhou Traditional Chinese Medicine Hospital，Liuzhou 545001，China）

Abstract Objective：This study aims to explore the influence of traditional Chinese medicine directed penetration therapy instrument on pain and quality of life of cancer pain patients.Methods：A total of 120 patients with cancer pain who were treated in Department of Oncology，Liuzhou Traditional Chinese Medicine Hospital From January 2018 to December 2019 were enrolled.They were divided into two groups（control group and observation group，60 cases in each） with the random number table method.Patients in the control group were treated with three-step analgesic ladder，and those in the observation group with traditional Chinese medicine directed penetration therapy.The following indexes were observed：pain grade after treatment，pain score（Visual Analog Scale，VAS） 1 day，7 days，and 14 days after treatment，onset time of analgesia，duration of pain relief，frequency of breakthrough cancer pain and eastern cooperative oncology group（ECOG） before and after treatment，and adverse reactions.Results：Before treatment，the pain grade，frequency of breakthrough cancer pain，and ECOG score were insignificantly different between the two groups（P>0.05）.After treatment，the pain grade，frequency of breakthrough cancer pain，and ECOG score were improved in both groups，particularly the observation group which showed significant difference from the control group（P<0.05）.No significant difference was observed in VAS score between the observation group and control group on day 1 after treatment，but the VAS score of the observation group was lower than that of the control group on day 7 and 14 after treatment（P<0.05）.The onset time of analgesia and the duration of pain relief in the observation group were shorter than those in the control group（P<0.05）.Constipation and nausea respectively occurred to 1 case in the control group，and drowsiness and constipation respectively happened to 1 case in the observation group（P>0.05）.Conclusion：The directed drug penetration therapy of traditional Chinese medicine can relieve the cancer pain of patients and improve their quality of life.0D14952A-1EE7-44D3-989D-AC89BA33CC50

Keywords Cancer pain; Three-step analgesic ladder; Directed drug penetration therapy instrument of traditional Chinese medicine; Frequency of breakthrough cancer pain; Pain grading; Pain scoring; Performance Status Scoring; Adverse reactions

中图分类号：R273文献标识码：Adoi：10.3969/j.issn.1673-7202.2022.08.014

慢性疼痛是临床常见疾病，可分为炎症痛、癌性疼痛、神经病理性痛等[1]。癌症患者多出现癌性疼痛，各种有害因素刺激下产生癌痛，影响患者心理状况、食欲及睡眠、治疗效果、生命质量[2-3]。我国……