杨雪松 付彧 毛慧玲 颜令义 房庆华 哈达 吕晓红 刘灵 陶宇

[摘要]目的：探究穩定期白癜风患者皮肤组织液sICAM-1水平的表达变化及与临床特征的关联性。方法：选择30例笔者医院收治确诊的稳定期白癜风患者为研究对象，其中寻常型20例，节段型10例，采用酶联免疫吸附法（ELISA）对白斑处和非白斑处皮肤组织液中的sICAM-1水平进行对比分析，并由专人记录患者的临床特征。结果：对稳定期白癜风患者的皮肤组织液sICAM-1水平进行检测：①寻常型白斑处sICAM-1水平明显高于非白斑处（P<0.05），且高于节段型（P<0.05）;②白斑处sICAM-1水平与病程呈负相关性（P<0.05），寻常型和节段型白斑处sICAM-1水平与病程均呈负相关性（P<0.05）;③白斑处sICAM-1水平与皮损面积呈正相关性（P<0.05）;④节段型白斑处sICAM-1水平与年龄呈负相关性（P<0.05）;⑤寻常型皮损面积大于节段型（P<0.05）。结论：稳定期白癜风患者白斑处皮肤组织液中sICAM-1水平表达异常，且与患者病程和皮损面积有关。

[关键词]白癜风;可溶性细胞间黏附分子-1;病程;皮损面积;年龄

[中图分类号]R758.4+1    [文献标志码]A    [文章编号]1008-6455（2021）06-0083-03

Correlation Analysis between the sICAM-1 in the Skin Tissue Fluid with Stable Vitiligo and Clinical Characteristics

YANG Xue-song1，FU Yu2，MAO Hui-ling3，YAN Ling-yi1，FANG Qing-hua1，HA Da1，LV Xiao-hong1，LIU Ling1，TAO Yu1

（1.Department of Dermatology，Daqing Longnan Hospital，the Fifth Affiliated Hospital of Qiqihar Medical University，Daqing 163453，Heilongjiang， China;2. Department of General Surgery，Daqing Oilfield General Hospital，Daqing 163001， Heilongjiang，China;3. Department of Science and Technology Management，Daqing Longnan Hospital，the Fifth Affiliated Hospital of Qiqihar Medical University， Daqing 163453，Heilongjiang，China）

Abstract： Objective  The correlation analysis between the sICAM-1 in the skin tissue fluid with stable vitiligo and clinical characteristics were investigated. Methods Selected 30 patients with stable vitiligo， including 20 patients with vitiligo vulgaris and 10 patients with segmental vitiligo.The levels of sICAM-1 in the skin tissue fluid at white spots and non-white spots were compared and analyzed by enzyme-linked immunosorbent assay （ELISA）.The patient's clinical characteristics were recorded by the same person. Results  The levels of sICAM-1 in the skin tissue fluid with stable vitiligo were detected： ①The levels of sICAM-1 in the white spots with vitiligo vulgaris was significantly higher than that in the non-white spots （P<0.05）， and higher than that with segmental vitiligo （P<0.05）. ②There was a negative correlation between the levels of sICAM-1 and course of disease in white spots （P<0.05）.There was a negative correlation between the levels of sICAM-1 and course of disease in white spots with vitiligo vulgaris（P<0.05）. There was a negative correlation between the levels of sICAM-1 and course of disease in white spots with segmental vitiligo（P<0.05）.③There was a positive correlation between the levels of sICAM-1 and lesion area in white spots（P<0.05）. ④There was a negative correlation between the levels of sICAM-1 and age in white spots with segmental vitiligo（P<0.05）. ⑤The lesion area of vitiligo vulgaris was larger than that of segmental vitiligo （P<0.05）. Conclusion  The expression of sICAM-1 in the skin tissue fluid with stable vitiligo was abnormal， which was related to the course of disease and lesion area.

Key words： vitiligo; sICAM-1; course of disease;lesion area;age

白癜风是一种自身免疫功能出现障碍导致黑素细胞特异性损伤的疾病[1-2]，其发生发展和自身免疫失衡有关[3]。体内的细胞因子可以通过合成和分泌的相互反馈以及调节作用、其受体表达的相互影响调节作用、生物学效应的影响等，形成一个非常复杂的免疫调节网络[4-5]。国外研究发现，在患者的白斑处真皮中淋巴细胞上移至表皮，且黑素细胞的破坏与淋巴细胞的浸润同步出现，推测两者之间存在联系[6]。细胞间黏附分子（ICAM-1）是淋巴细胞功能相关抗原（LFA-1）的特異性配体，经研究证实其在淋巴细胞攻击黑素细胞中发挥重要的连接作用[7]。而可溶性细胞间黏附分子-1（sICAM-1）是ICAM-1的脱落循环形式，血清中ICAM-1表达增加，其脱落形式sICAM-1表达也相应增加[8]。本研究检测稳定期白癜风患者皮肤组织液中sICAM-1水平，探究其与白癜风患者临床特征的关联性，现报道如下。……