应航宇　任金平　戚敏敏　袁丞达

[關键词] 邬氏活血祛斑方;气滞血瘀型;黄褐斑;严重指数;自我评价满意度

[中图分类号] R758.4          [文献标识码] B          [文章编号] 1673-9701（2021）23-0133-04

Study on the  clinical  efficacy of Wu's Huoxue Quban Recipe on female chloasma with qi stagnation and blood stasis

YING Hangyu   REN Jinping   QI Minmin   YUAN Chengda

Department of Dermatology， Hangzhou Hospital of TCM， Hangzhou   310007， China

[Abstract] Objective To analyze and explore the clinical efficacy of Wu's Huoxue Quban Recipe in the treatment of female chloasma with qi stagnation and blood stasis. Methods A total of 80 female patients with chloasma of qi stagnation and blood stasis who were treated in our hospital from February 2018 to October 2020 were selected. According to the random number table method， the patients were divided into the control group and the study group， with 40 cases in each group. Patients in the control group were given conventional western medicine treatment， and patients in the study group were given Wus Huoxue Quban Recipe on the basis of the control group. The clinical efficacy， self-treatment satisfaction evaluation and serum sex hormone levels were compared between the two groups of patients. Results The chloasma area， severity index， and subjective evaluation in the study group were better than those in the control group， and the difference was statistically significant （P<0.05）; the self-evaluation satisfaction with treatment in the patients in the study group was higher than that in the control group， and the difference was statistically significant （P<0.05）; after treatment， the levels of serum follicle stimulating hormone （FSH）， luteinizing hormone （LH）， and estradiol （E2） in the study group were lower than those in the control group， and the differences were statistically significant（P<0.05）; there was no significant difference in progesterone （P） levels between the two groups （P>0.05）. Conclusion Research data show that the application of Wu's Huoxue Quban Recipe in the treatment for female patients with chloasma of qi stagnation and blood stasis can not only effectively improve the patient's serum sex hormone level， but also improve the patient's chloasma area and color. It improves the patient's self-satisfaction with the treatment effect， and the clinical value is obvious.

[Key words] Wu's Huoxue Quban Recipe; Type of qi stagnation and blood stasis; Chloasma; Severity index; Self-evaluation of satisfaction

黄褐斑是中青年妇女中较为常见的一种皮肤疾病，临床多表现为面部条形、圆形、蝴蝶型的黄褐色斑片深浅不一分布，对患者的外貌影响较大，不仅会导致患者的外貌自信心下降，同时对于患者的工作、生活也会造成一定的不利影响[1]。目前临床对于黄褐斑的发病机制多认为是由于紫外线照射、内分泌失调、妊娠以及生活习惯等因素造成的。临床传统的治疗多是使用维生素等抗氧化药物对其进行治疗，借此对黑色素的合成能力进行降低，同时可辅助激光治疗、脱色剂等方式，对色斑进行有效淡化，但目前发现其治疗效果有限，且对人体存在一定的伤害和影响[2]。而中医治疗的效果近几年不断显现，研究中发现，中医组方不仅对黄褐斑治疗效果明显，同时对于人体的损害极小。围绕邬氏活血祛斑方对女性气滞血瘀型黄褐斑进行治疗的临床效果进行分析研究。

1 资料与方法

1.1 一般资料

选取2018年2月至2020年10月期间来我院接受治疗的气滞血瘀型女性黄褐斑患者80例，依随机数字表法将患者分为对照组和研究组。研究组40例，平均年龄（43.62±6.84）岁，平均病程（11.06±1.57）月;对照组40例，平均年龄（42.74±5.69）岁，平均病程（10.62±0.96）月;两组患者的临床资料比较，差异无统计学意义（P>0.05）。本研究经医院伦理委员会审批通过，患者以及家属均了解内容并自愿参与研究。