王芳 陈洁 刘宇涵 庞硕勋 杨海燕

摘要 目的：探討通心络胶囊联合倍他乐克对冠心病稳定型心绞痛患者心功能的影响。方法：选取2018年1月至2020年1月河北以岭医院收治的冠心病稳定型心绞痛患者84例作为研究对象，按照随机数字表法分为对照组和观察组，每组42例。对照组在常规治疗基础上给予倍他乐克。观察组在对照组治疗基础上给予通心络胶囊治疗。对比2组的疗效、中医证候评分、超声心动图指标[左心室射血分数（LVEF）、左心室舒张末期内径（LVEDD）、左心室收缩末内径（LVESD）]、血脂指标[总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）]、心绞痛发作情况、不良反应发生率。结果：观察组的治疗效果好于对照组（P<0.05）。2组治疗后的中医证候评分、LVEDD、LVESD、TG、TC、LDL-C、心绞痛发作频率、发作持续时间降低，LVEF、HDL-C增高。观察组的中医证候评分、LVEDD、LVESD、TG、TC、LDL-C、心绞痛发作频率、发作持续时间低于对照组，LVEF、HDL-C高于对照组（均P<0.05）。2组的不良反应发生率比较，差异无统计学意义（P>0.05）。结论：通心络胶囊联合倍他乐克治疗冠心病稳定型心绞痛患者，可提高临床疗效，改善心功能，降低血脂水平，减少心绞痛的发作，安全性良好。

关键词 通心络胶囊;倍他乐克;冠心病;稳定型心绞痛;动脉粥样硬化;心肌缺血;血脂;中医

Effects of Tongxinluo Capsuless Combined with Betaloc on Cardiac Function in Patients with Stable Angina Pectoris of Coronary Heart Disease

WANG Fang1，CHEN Jie1，LIU Yuhan1，PANG Shuoxun2，YANG Haiyan3

（1 Cardiovascular Department，Hebei Yiling Hospital，Shijiazhuang 050000，China; 2 Department of Cardiac Rehabilitation，Shijiazhuang Great Wall Integrated Chinese and Western Medicine Hospital Heart Rehabilitation Hebei，Shijiazhuang 050000，China; 3 Department of Cardiology，Hebei 8th People′s Hospital，Shijiazhuang 050000，China）

Abstract Objective：To investigate the effects of Tongxinluo Capsules combined with betaloc on cardiac function in patients with stable angina pectoris of coronary heart disease.Methods：A total of 84 patients with stable angina pectoris of coronary heart disease admitted to Hebei Yiling Hospital from January 2018 to January 2020 were selected as research objects.According to random number table method，they were divided into a control group and an observation group，with 42 cases in each group.The control group was given Betaloc on the basis of conventional treatment.The observation group was given Tongxinluo Capsules treatment on the basis of the treatment of the control group.The efficacy，TCM symptom score，echocardiographic index[left ventricular ejection fraction（LVEF），left ventricular end diastolic diameter（LVEDD），left ventricular end systolic diameter（LVESD）]，blood lipid index[total cholesterol（TC），triglycerides（TG），low-density lipoprotein cholesterol（LDL-C），high-density lipoprotein cholesterol（HDL-C）]，angina pectoris，adverse reactions were compared.Results：The treatment effect of the observation group was better than that of the control group（P<0.05）.After treatment，the TCM symptom scores，LVEDD，LVESD，TG，TC，LDL-C，angina pectoris frequency，duration of attacks of the two groups all decreased，and LVEF and HDL-C increased.The TCM syndrome score，LVEDD，LVESD，TG，TC，LDL-C，angina pectoris frequency and duration of attacks of the observation group were lower than those of the control group，while LVEF and HDL-C were higher than those of the control group（all P<0.05）.There was no statistically significant difference in the incidence of adverse reactions between the 2 groups（P>0.05）.Conclusion：Tongxinluo Capsules combined with Betaloc in the treatment of patients with stable angina pectoris of coronary heart disease can improve clinical efficacy，improve heart function，reduce blood lipid levels and the onset of angina pectoris，and has good safety.

Keywords Tongxinluo Capsules; Betaloc; Coronary heart disease; Stable angina pectoris; Atherosclerosis; Myocardial ischemia; Blood lipid; Traditional Chinese medicine

中图分类号：R256.2文献标识码：Adoi：10.3969/j.issn.1673-7202.2021.17.016

冠心病的全称为冠状动脉粥样硬化性心脏病，該种疾病已经成为我国人群的高发慢性心血管疾病，尤其在中老年人群之中，所造成的健康损失、寿命损失均较为严重[1-2]。在全球以及我国人口均出现十分明显的老龄化趋势背景下，冠心病的罹患人数也在持续增加[3]。冠心病可以分为多个亚型，其中稳定型心绞痛属于其中一类较为常见的临床亚型[4]。冠心病稳定型心绞痛是人体的冠状动脉粥样硬化或者痉挛等导致的血管管腔狭窄，诱发心肌缺血缺氧，严重者发生坏死等，患者可有胸部不适、胸痛等典型的临床表现[5-6]。……