伍红星 陈雅恒 余延云

[摘要]目的研究氟哌啶醇联合五维赖氨酸颗粒在儿童抽动症中的应用。方法选取2018年10月至2020年10月中山市人民医院儿童康复治疗科收治的150例抽动症患儿作为研究对象，随机分为试验组和对照组，每组各75例。对照组口服氟哌啶醇，试验组联合服用氟哌啶醇和五维赖氨酸颗粒。比较两组临床疗效、肌肉功能、肾功能、神经功能指标及不良反应发生率。结果试验组的治疗总有效率高于对照组，治疗后肌肉功能评分低于对照组，差异均有统计学意义（P <0.05）;治疗后两组血尿素氮（BUN）和血肌酐（Scr）指标、不良反应发生率比较，差异均无统计学意义（P >0.05）;治疗后，试验组γ-氨基丁酸（GABA）、去甲肾上腺素（NE）和5-羟色胺（5-HT）水平低于对照组，血清神经生长因子（NGF）水平高于对照组，差异有统计学意义（P <0.05）。结论氟哌啶醇联合五维赖氨酸颗粒对儿童抽动症有较好的治疗效果，且未增加不良反应发生率，具有显著临床应用价值。[关键词]氟哌啶醇;五维赖氨酸颗粒;儿童抽動症;肌肉功能;神经功能

[中图分类号] R749.94 [文献标识码] A  [文章编号]2095-0616（2021）22-0073-04

The application of haloperidol combined with five vitamins and lysine granules to the children with Tourette syndrome and the effect on muscle function， neurological function and nerve growth factor

WU  Hongxing   CHEN  Yaheng   YU  Yanyun

Department of Children Rehabilitation， Zhongshan City People's Hospital， Guangdong， Zhongshan 528400， China

[Abstract] Objective To study the application of haloperidol combined with five vitamins and lysine granules to the children with Tourette syndrome （TS）. Methods A total of 150 children with Tourette syndrome admitted to and treated in Department of Children Rehabilitation of Zhongshan City People's Hospital from October 2018 to October 2020 were taken as the subjects of research. They were randomly divided into the experimental group and the control group with 75 patients in each group. The control group was administered haloperidol orally， while the experimental group took haloperidol combined with five vitamins and lysine granules orally. The clinical efficacy and other indices were compared between the two groups. Results The total effective rate of the experimental group was higher than that of the control group， and the muscle function scores after treatment were lower than those of the control group， and the differences were statistically significant （P <0.05）. After treatment， there were no statistically significant differences in blood urea nitrogen （BUN）， serum creatinine （Scr） indicators and the incidence of adverse reactions （ADRs） between the two groups （P >0.05）. After treatment， the levels of γ-aminobutyric acid （GABA）， norepinephrine （NE） and 5- hydroxytryptamine （5-HT） in the experimental group were lower than those in the control group， and the level of nerve growth factor （NGF） in the serum was higher than that in the control group， and the differences were statistically significant （P <0.05）. Conclusion Haloperidol combined with five vitamins and lysine granules produces satisfying curative effect on the children with TS without raising the incidence of ADRs. It has significant clinical application value.

[Key words] Haloperidol; Five vitamins and lysine granules; The children with Tourette syndrome; Muscle function; Neurological function

抽动症是一种慢性神经精神障碍性疾病，多发于儿童期，研究指出其发病原因与遗传、环境或心理因素有关[1-3]。该病临床表现为肌肉无节律抽动、发声性抽动、常伴喉部发声等，且多数患儿同时伴有学习困难、情绪及睡眠障碍等症状，严重影响患儿身体发育及正常的学习生活[3-5]。目前儿童抽动症的治疗方案多采用单一服药方案，但疗效不佳且治疗周期长，停药后易复发等。五维赖氨酸颗粒是以赖氨酸为主要成分，是治疗儿童类疾病的常用药物[6-8]。本研究以150例抽动症患儿为研究对象，联合服药氟哌啶醇和五维赖氨酸颗粒，分析其临床治疗效果，现报道如下。

1资料与方法

1.1一般資料

选取2018年10月至2020年10月中山市人民医院儿童康复治疗科收治的150例抽动症患儿作为研究对象，随机分为试验组和对照组，每组各75例。……