赖凌燕 蒋辉

[摘要]目的研究尼可地尔治疗稳定型心绞痛患者的疗效，并进行药学分析。方法选取2019年10月至2020年9月福建省立医院心血管内科收治的200例稳定型心绞痛患者作为研究对象，根据随机数字表法分为对照组和观察组，每组各100例，对照组实施常规治疗，观察组在进行常规治疗的同时辅以尼可地尔治疗。比较两组的心绞痛发作情况、心功能指标、实验室检查结果、临床疗效和用药安全性。结果观察组患者治疗后的心绞痛发作次数少于对照组，发作持续时间短于对照组，差异有统计学意义（P <0.05）;观察组患者治疗后的左室射血分数（LVEF）、左室短轴缩短分数（LVFS）、心脏指数（CI）、一氧化氮（NO）水平及治疗总有效率高于对照组，血清五聚素-3（PTX3）、脂蛋白相关磷脂酶 A2（Lp-PLA2）、血浆内皮素-1（ET-1）水平低于对照组，差异有统计学意义（P <0.05）;两组用药安全性比较差异无统计学意义（ P >0.05）。结论在稳定型心绞痛的治疗中辅以尼可地尔具有较高的有效性和用药安全性，能够减轻心绞痛症状和改善心功能。[关键词]稳定型心绞痛;尼可地尔;药学;心绞痛症状;心功能

[中图分類号] R541.4 [文献标识码] A  [文章编号]2095-0616（2021）22-0069-04

Therapeutic effect and pharmaceutical analysis of nicorandil on patients with stable angina pectoris

LAI  Lingyan   JIANG  Hui

Department of Pharmacy， Fujian Provincial Hospital， Fujian， Fuzhou 350001， China.

[Abstract] Objective To study the curative effect of nicorandil on patients with stable angina pectoris （SAP）， and to make pharmaceutical analysis. Methods A total of 200 SAP patients admitted to the Department of Cardiovascular Medicine of Fujian Provincial Hospital from October 2019 to September 2020 were selected as the research objects， and were randomly divided into the control group and the observation group， with 100 cases in each group. The control group was given conventional treatment， while the observation group was given conventional treatment combined with nicorandil. The incidence of angina pectoris， cardiac function index， laboratory test results， clinical efficacy and medication safety were compared between the two groups. Results After treatment， the incidence and duration of angina pectoris in the observation group were less than those in the control group， with statistically significant differences （P <0.05）. The levels of left ventricular ejection fraction （LVEF）， left ventricular fractional shortening （LVFS）， cardiac index （CI）， nitric oxide （NO） and the total effective rate after treatment in the observation group were higher than those in the control group， while the levels of serum pentraxin-3（PTX3）， lipoprotein-associated phospholipase A2（Lp-PLA2） and plasma endothelin-1（ET-1） were lower than those in the control group， with statistically significant differences （P <0.05）. There was no significant difference in medication safety between the two groups （P >0.05）. Conclusion Nicorandil is effective and safe in the treatment of SAP， which can alleviate AP symptoms and improve heart function.

[Key words] Stable angina pectoris; Nicorandil; Pharmacy; Symptoms of angina pectoris; Cardiac function

心绞痛可分为稳定型心绞痛与不稳定型心绞痛[1]，其中稳定型心绞痛是冠心病的常见类型，情绪激动、体力劳动、气候等均可能诱发该病[2]，以阵发性胸骨后压榨性疼痛为主要表现，会对患者的日常运动耐量产生影响，导致患者生活质量下降。药物治疗是控制稳定型心绞痛病情的主要方法，临床常使用阿司匹林等药物对该病进行治疗，虽然可使心绞痛症状得到一定的缓解，但是临床疗效并未能达到预期[3]。尼可地尔属于钾离子通道开放药[4]，在各类心绞痛的治疗中广泛应用，本研究进一步分析尼可地尔在稳定型心绞痛患者中的疗效，旨在为临床用药方案的制订提供参考依据。……