常雪 陈晓婧 张旭东 张超伟 李永乐 白燕

摘要 消化系统疾病是临床中常见病、多发病，临床表现纷繁复杂，疾病之间相互关联，严重影响患者生命质量。细胞自噬是维护胃黏膜细胞稳态的重要因素，是导致消化系统疾病发病的重要环节。中医药作为临床防治消化系统疾病的重要干预措施之一，其防治作用及机制成为近年来研究的重要方向。本文通过收集相关文献资料，重点从ULK1蛋白激酶复合体、Vps34-Beclin1和Ⅲ型PI3K复合体、mAtg9、Atg5-Atg12-Atg16连接系统和LC3连接系统中具体信号通路及相关蛋白分析近年来中医药对消化系统疾病细胞自噬的调控的研究现状，以期发现中医药调节自噬对于细胞保护的作用，从而对于中医药防治消化系统疾病提供依据。

关键词 消化系统疾病;自噬;中医药;ULK1蛋白激酶复合体;Vps34-Beclin1;Ⅲ型PI3K复合体;mAtg9;Atg5-Atg12-Atg16连接系统;LC3连接系统;综述

Research Status of Chinese Medicine Regulating Autophagy to Prevent and Cure Digestive System Diseases

CHANG Xue1，CHEN Xiaojing1，ZHANG Xudong1，ZHANG Chaowei1，LI Yongle1，BAI Yan2

（1 College of Traditional Chinese Medicine，Inner Mongolia Medical University，Hohhot 010110，China; 2 The Fourth Affiliated Hospital of Inner Mongolia Medical University，Baotou 0140000，China）

Abstract Digestive system diseases are common and frequently-occurring diseases in clinical practice.The clinical manifestations are complex and complicated.The diseases are interrelated，which seriously affects the quality of life of patients.Cell autophagy is an important factor in maintaining the homeostasis of gastric mucosal cells and an important link in the pathogenesis of digestive system diseases.As one of the important intervention measures for clinical prevention and treatment of digestive system diseases，Traditional Chinese medicine（TCM）has become an important research direction in recent years.This paper collect relevant literature and focuses on the analysis of specific signal pathways and related proteins in the ULK1 protein kinase complex，Vps34-Beclin1 and type Ⅲ PI3K complex，mAtg9，Atg5-Atg12-Atg16 connection system and LC3 connection system in recent years.The current status of research on the regulation of digestive system disease cell autophagy，with a view to discovering the role of TCM in regulating autophagy on cell protection，so as to provide a basis for the prevention and treatment of digestive system disease by Chinese medicine.

Keywords Digestive system diseases; Autophagy; Traditional Chinese medicine;ULK1 protein kinase complex; Vps34-Beclin1; Type Ⅲ PI3K Complex; mAtg9; Atg5-Atg12-Atg16 junction system; LC3 junction system; Review

中圖分类号：R256.3;R259文献标识码：Adoi：10.3969/j.issn.1673-7202.2021.03.030

消化系统疾病是临床中的常见病、多发病，多由内外源性损伤因素使胃黏膜保护屏障受损及细胞因子失调引起胃黏膜损伤导致相关疾病发生，如早期胃癌、慢性非萎缩性胃炎、胃黏膜的肠上皮化生等等，多种疾病之间相互影响，致使患者生命质量明显降低，因此修复胃黏膜损伤，恢复其屏障作用，有助于临床防治消化系统疾病及进一步恶化。对于发病机制，目前仍不明确，从现代医学学的角度来讲[1-2]，该疾病的产生受到一系列不同因素的影响，比如，环境因素、心理因素、吸烟以及细菌感染等等。临床常以根除幽门螺杆菌感染、改善患者胃肠蠕动力、保护胃黏膜等为常用治疗措施，由于相关治疗药物不良反应较多，导致在使用过程中存在胃病患者对药物的服用及治疗依从性受限[3-4]。……