王磊 安永辉��

【摘 要】 目的：观察中西医结合治疗帕金森病共病抑郁的临床疗效。方法：选取帕金森病共病抑郁对象68例 按就诊顺序 采用单双号法将其分为对照组和观察组各34例。比较治疗前后两组帕金森病症状、抑郁症状、用药期间不良事件发生率及治疗结束后随访半年的生存质量。结果：随访半年相比治疗前 两组躯体功能、心理功能、社会功能、物质生活状态及总体生活质量评分均升高 且随访半年对照组躯体功能、心理功能、社会功能、物质生活状态及总体生活质量评分均低于观察组（P<0.05）;治疗4周、8周 对照组药物副反应量表（TESS）评分高于观察组（P<0.05）;对照组帕金森病共病抑郁治疗总有效率均低于观察组（P<0.05）。结论：中西医结合治疗帕金森病共病抑郁收效较好。

【关键词】 帕金森病;抑郁;中西医结合

Abstract：Objective To observe the effect of integrated traditional Chinese and western medicine in the treatment of Parkinsons disease comorbid depression.Methods Select 68 patients with Parkinsons disease comorbid depression. According to the order of treatment， the included objects were divided into a control group and an observation group （34 cases in each） by the odd and even number method.The incidence of Parkinsons disease symptoms， depressive symptoms， adverse events during medication and the quality of life of the included subjects before and after treatment were compared.Results Follow-up for six months compared to before treatment， the scores of physical function， psychological function， social function， material life status and overall quality of life of the two groups were increased， and the scores of physical function， psychological function， social function， material life status and overall quality of life of the control group were lower than those of the observation group（P<0.05）. After 4 weeks and 8 weeks of treatment， the TESS score of the control group was higher than that of the observation group（P<0.05）. The total effective rate of Parkinsons disease comorbid depression treatment in the control group was lower than that in the observation group（P<0.05）.Conclusion The combination of traditional Chinese and Western medicine in the treatment of depression of Parkinsons disease comorbidity is effective.

Keywords：Parkinsons Disease; Depression; Lntegrated Chinese and Western Medicine

帕金森病是一種以静止性震颤、肌肉强直和运动迟缓为主要特征的慢性进展性神经系统退行性病变 除上述运动特征外 抑郁、消化道症状和睡眠障碍作为其非运动特征同样影响着病情进程和预后[1-2] 尤其共病抑郁可加速运动障碍、增加临床治疗难度 使致残率倍增 倍受临床关注[3]。现代医学对于帕金森病共病抑郁的治疗仍以抗震颤麻痹联合抗抑郁药物等对症干预为主 此类药物虽能控制临床症状、改善患者生活质量 但长期服用所引发的药物不良反应和耐受性随之升高 影响临床疗效[4]。近年来有关中医干预帕金森病共病抑郁的临床优势被不断肯定[5];虽然相关文献报道甚多 但角度不同 尚未形成标准化的治疗方案得以推广使用。本研究结合中医理论对帕金森病共病抑郁的认知 以固本开郁法作为基本原则并运用其中 观察中西医结合治疗该病的效果，现报告如下。……