张哲 盖子璇

[摘要] 目的 探讨sdLDL-C对糖尿病患者早期肾损伤的评估价值。 方法 随机收集2017年9月至2019年9月我院糖尿病肾病患者33例作为观察组，同期选取33例健康人群作为对照组。对所有人群进行血糖、糖化血红蛋白（HbA1c）、小而密低密度脂蛋白胆固醇（sdLDL-C）、總胆固醇、三酰甘油、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A、载脂蛋白B、同型半胱氨酸（Hcy）、胱抑素C指标的检查，对比其检查结果，并且计算出尿蛋白排泄率（UAER）以及肾小球滤过率（eGFR），并进行深入分析。 结果 观察组血糖、HbA1c、sdLDL-C、总胆固醇、三酰甘油、LDL-C、载脂蛋白B、Hcy及胱抑素C高于对照组，HDL-C、载脂蛋白A均低于对照组，观察组UAER高于对照组，eGFR低于对照组（P<0.05）。 结论 sdLDL-C在糖尿病患者早期肾损伤的评估中价值显著，适合在临床进行开展和实施。

[关键词] sdLDL-C;糖尿病;早期肾损伤;评估价值

[中图分类号] R248.3          [文献标识码] B          [文章编号] 1673-9701（2021）07-0133-03

The evaluation value of sdLDL-C for early renal injury in diabetic patients

ZHANG Zhe   GE Zixuan

Department of Laboratory Medicine， the People′s Hospital of Xing′an League in Inner Mongolia Autonomous Region， Ulanhot   137400， China

[Abstract] Objective To explore the evaluation value of sdLDL-C for early renal injury in diabetic patients. Methods Thirty-three cases were randomLy selected from the diabetic nephropathy patients in our hospital from September 2017 to September 2019 as the subject of this study， named the observation group. And 33 healthy people were selected during the same period as the control group. Blood glucose， glycosylated hemoglobin， small and dense low-density lipoprotein cholesterol， total cholesterol， triacylglycerol， high-density lipoprotein cholesterol， low-density lipoprotein cholesterol， apolipoprotein A，apolipoprotein B， homocysteine， Cystatin C for all people were detected. The results of the examination were compared， and the urine protein excretion rate and glomerular filtration rate were calculated. An in-depth analysis was conducted. Results The blood glucose， HbA1c， sdLDL-C ，total cholesterol， triacylglycerol， LDL-C， apolipoprotein B， Hcy， and Cystatin C in the observation group were higher than those of the control group. The HDL-C and apolipoprotein A of the observation group were lower than those of the control group. The UAER  of the observation group was higher than that of the control group. The eGFR  of the observation group was lower than that of the control group（P<0.05）. Conclusion sdLDL-C has significant value in evaluating early renal injury in diabetic patients， and is suitable for clinical development and implementation.

[Key words] sdLDL-C; Diabetes; Early renal injury; Evaluation value

糖尿病肾病是临床上常见的疾病，为糖尿病患者的并发症之一，也是发生终末期肾脏病的主要原因。随着临床糖尿病发生率的升高，糖尿病肾病的发病率也逐年升高。糖尿病肾病的发病机制复杂，与血脂、脂蛋白异常等息息相关[1]，因此，临床往往将血脂、脂蛋白检测等作为检测糖尿病肾病的主要方向。低密度脂蛋白可以分为大而轻低密度脂蛋白和小而密低密度脂蛋白（Small dense low-density lipoprotein，sdLDL-C）两种[2]，小而密低密度脂蛋白更容易被氧化，从而促使泡沫细胞的形成，进而促使动脉粥样硬化的形成[3]。本文将对SdLDL-C对糖尿病患者早期肾损伤的评估价值进行深入分析，现报道如下。

1 资料与方法

1.1 一般资料

选取2017年9月至2019年9月在本院接受治疗的糖尿病肾病患者33例作为观察组，同期选取33例健康人群，作为对照组。……