王文涛　　王伽利

[摘要] 目的 探讨清淋方联合坦索罗辛治疗前列腺增生电切术后膀胱过度活动症的效果。 方法 回顾性选取本院2017年1月至2019年12月收治的前列腺增生行电切术后膀胱过度活动症患者97例，根据其用药的不同分为常规组（n=46，坦索羅辛）与联合组（n=51，坦索罗辛+清淋方），疗程为12周。比较两组患者治疗前后症状的变化，记录用药期间出现的不良反应，治疗前后对两组患者进行各项症状评分：国际前列腺症状评分（IPSS）、膀胱过度活动症状评分（OABSS）、储尿期症状评分（USPSS）、排尿期症状评分（VSS），评价两组治疗的总有效率。 结果 治疗后两组症状均有一定程度改善，治疗后联合组最大尿流量多于常规组，且膀胱痉挛次数及持续时间均少于常规组，差异均有统计学意义（P<0.05）;经治疗后两组各症状评分均有所降低（P<0.05），治疗后联合组IPSS、OABSS、USPSS低于常规组（P<0.05）;两组不良反应发生率比较，差异无统计学意义（P>0.05）;联合组临床总有效率高于常规组（P<0.05）。 结论 与单用坦索罗辛相比，清淋方联合坦索罗辛治疗前列腺增生电切术后膀胱过度活动症，能进一步改善患者症状，提高临床疗效。

[关键词] 坦索罗辛;清淋方;前列腺增生;膀胱过度活动症

[中图分类号] R983          [文献标识码] B          [文章编号] 1673-9701（2021）06-0130-04

Effect of Qinglin Decoction combined with tamsulosin in the treatment of overactive bladder after electrocision of prostate hyperplasia

WANG Wentao   WANG Jiali

Department of Urinary Surgery， Fushun Second Hospital in Liaoning Province， Fushun   113001， China

[Abstract] Objective To explore the effect of Qinglin Decoction combined with tamsulosin in the treatment of overactive bladder after electrocision of prostate hyperplasia. Methods A total of 97 patients with overactive bladder after electrocision of prostate hyperplasia who were admitted in our hospital from January 2017 to December 2019 were retrospectively selected. According to their different medications， they were divided into two groups： the conventional group（n=46， tamsulosin） and the combination group （n=51， tamsulosin+Qinglin decoction）. The course of treatment was 12 weeks. The changes in symptoms were compared between the two groups before and after treatment. Adverse reactions of medications were recorded. The symptoms occurring in both groups before and after treatment were scored： International prostate symptom score （IPSS）， Overactive bladder symptom Score （OABSS）， Urinary storage symptom score （USPSS）， and Vertigo symptom score（VSS）. The total effective rate was evaluated in both groups of treatment. Results After treatment， the symptoms in both groups were improved to a certain extent. After treatment， the maximum urine flow in the combination group was more than that in the conventional group. Moreover， the number and duration of bladder spasm were less than those in the conventional group， and the above differences were statistically significant（P<0.05）; after treatment， the symptom scores in both groups were reduced （P<0.05）. After treatment， the IPSS， OABSS and USPSS in the combination group were lower than those in the conventional group（P<0.05）; the difference in the incidence rate of adverse reactions between the two groups was not statistically significant （P>0.05）; the total clinical effective rate in the combination group was higher than that in the conventional group（P<0.05）. Conclusion Compared with tamsulosin alone， tamsulosin combined with Qinglin decoction in the treatment of overactive bladder after electrocision of prostate hyperplasia can further improve the symptoms of patients and improve the clinical efficacy.

[Key words] Tamsulosin; Qinglin decoction; Prostate hyperplasia; Overactive bladder

前列腺增生是临床常见的男性疾病，尤其在老年男性中高发，文献指出我国50岁以上男性人群中发病率高达30%～50%，70岁以上男性人群中可高达70%[1-2]。临床上常采用电切术治疗前列腺增生，电切术能通过切除前列腺增生腺体从而缓解患者的临床症状，但术后容易并发膀胱过度活动症[3]。膀胱过度活动症是以尿急为主要特征的症候群，常伴有尿频与夜尿，甚至会伴随急迫性尿失禁，给患者生活造成了极大的困扰[4]。目前治疗的药物主要包括各类受体阻滞剂[5]。坦索罗辛是一种α1肾上腺素受体阻滞剂，可以改善膀胱平滑肌张力，被广泛用于男性泌尿生殖系统疾病中[6]。……