李昊 罗文平 杨震

[摘要]目的：探討PerioGlas骨替代材料在上颌前牙区骨量不足种植术中的效果。方法：选择2016年6月-2018年6月笔者科室收治的65例上颌前牙区周围骨缺损种植患者，通过随机数表法分为观察组和对照组，均行口腔种植术治疗。对照组：30例，术中植入Bio-Oss骨粉，观察组：35例，术中植入PerioGlas骨替代材料。对所有患者随访1年，比较两组种植体存留率、唇侧骨量、骨密度、红色美学指数（PES）及不良反应。结果：随访显示，两组种植体存留率均为100%;两组术后即刻唇侧骨量、骨密度比较差异无统计学意义（P>0.05），术后6个月、12个月，观察组唇侧骨量、骨密度及PES评分均明显高于对照组（P<0.05）;随访期间，两组均无排异现象，无感染、过敏等局部或全身不良反应。结论：Perio Glas骨替代材料在上颌前牙区骨量不足种植术中的应用效果明显，有助于促进骨生长，提高美学效果，值得临床推广应用。

[关键词]上颌前牙;骨缺损;口腔种植;Bio-Oss骨粉;PerioGlas骨替代材料

[中图分类号]R782.12    [文献标志码]A    [文章编号]1008-6455（2021）03-0138-04

Analysis of the Effect of PerioGlas Bone Substitute Material in Treatment of Maxillary Anterior Teeth with Bone Insufficiency Implantation

LI Hao1， LUO Wen-ping2，YANG Zhen3

（1.Department of Stomatology， Hankou Hospital，Wuhan 430010，Hubei，China;2. Department of Stomatology， Wuchang Hospital， Wuhan 430063， Hubei，China;3.Wuhan Dental Clinic， Wuhan 430010，Hubei，China）

Abstract： Objective  To study the effect of PerioGlas bone substitute material in treatment of maxillary anterior teeth with bone insufficiency implantation. Methods 75 patients with maxillary anterior teeth peripheral bone defect who received therapy from June 2016 to June 2018 in dental Department of our hospital were selected， they were divided into the 35 casees in the observation group and 30 cases in the control group by the the random number table， they were performed oral implantation， the control group was implanted Bio-Oss bone powder during operation， the observation group was implanted PerioGlas bone substitute during operation. They were followed up for one year， the implant retention rate， labial bone mass， bone mineral density， red aesthetic index （PES） and adverse reactions were compared between the two groups. Results  The follow-up showed that the implant retention rate in two groups was 100%.There was no significant difference in labial bone mass and bone mineral density between the two groups immediate postoperative（P>0.05）.  The labial bone mass， bone mineral density and PES scores in the observation group were significantly higher than those in the control group at after operation 6 and 12 months （P<0.05）. During the follow-up period， there was no rejection and no local or systemic adverse reactions such as infection or allergy in both groups.  Conclusion The PerioGlas bone substitute material is well for maxillary anterior teeth with bone insufficiency implantation， which can effectively promote bone growth and improve aesthetic effect， which is worth popularizing.

Key words： maxillary anterior teeth; bone defect; oral implantation; Bio-Oss bone powder; PerioGlas bone substitute material

决定口腔种植成功的重要条件则是种植区骨量充足，但在一些伴有牙槽骨缺损的或者牙缺失时间过长的患者中，存在着一定牙槽骨吸收、牙槽骨骨量不足等现象，不仅为口腔种植修复增加了困难，也容易影响种植修复后的美学效果，严重者甚至出现种植体脱落等[1-2]。如何提高对此类患者的治疗效果也是诸多口腔医学者的研究重点，目前认为，有效的骨替代材料在提高上颌前牙区周围骨缺损患者口腔种植修复疗效中作用关键，临床上应用较多的骨替代材料为Bio-Oss骨粉，具有较好的生物活性和骨传导性，但在部分研究中也发现，其吸收较为缓慢，成骨时间过长，也有部分患者疗效不足[3]。PerioGlas是一种与天然骨组织成分相似的骨替代材料，生物降解作用、骨诱导作用均较好，在口腔种植中具有较好的可塑性、黏附性及成骨效果[4]。因此……