韩冬

【摘要】 目的：探討血清可溶性糖蛋白链细胞因子亚单位130通路（gp130）和白细胞介素-6受体（IL-6R）水平与ST段抬高型心肌梗死（STEMI）患者心肌坏死的相关性。方法：回顾性分析2017年10月-2020年10月本院收治的85例STEMI患者的临床资料，依照冠状动脉病变情况将患者分为单支病变组（n=38）、双支病变组（n=26）和三支病变组（n=21）。对比三组血清可溶性gp130、IL-6R和IL-6水平情况并分析其与患者心肌坏死情况的相关性，根据住院期间和3年随访期间存活情况将患者分为死亡组（n=11）和存活组（n=74），对比两组各指标情况，并分析可溶性gp130、IL-6R和IL-6水平对STEMI患者预后的预测价值。结果：三组血清可溶性gp130、IL-6R和IL-6水平对比，差异均有统计学意义（P<0.05），三支病变组高于双支病变组高于单支病变组。Spearman相关分析结果显示：血清可溶性gp130、IL-6R和IL-6水平与STEMI患者心肌坏死情况均呈正相关（P<0.05）。生存组与死亡组性别对比，差异无统计学意义（P>0.05）;生存组与死亡组年龄、入院心率、gp130、IL-6R和IL-6对比，差异均有统计学意义（P<0.05）;logistic回归分析结果显示：gp130、IL-6R和IL-6均为STEMI患者预后的影响因素（P<0.05）。结论：STEMI患者心肌坏死情况与gp130和IL-6R水平关系密切，且对STEMI患者预后情况可能具有预测价值。

【关键词】 gp130 IL-6R ST段抬高型心肌梗死 心肌坏死

Correlation between Serum Soluble gp130 and IL-6R Levels and Myocardial Necrosis in Patients with ST-segment Elevation Myocardial Infarction/HAN Dong. //Medical Innovation of China， 2021， 18（28）： -137

[Abstract] Objective： To investigate the correlation between serum soluble glycoprotein chain cytokine subunit 130 pathway （gp130） and interleukin-6 receptor （IL-6R） levels and myocardial necrosis in patients with ST-segment elevation myocardial infarction （STEMI）. Method： The clinical data of 85 patients with STEMI treated in our hospital from October 2017 to October 2020 were retrospectively analyzed， the patients were divided into single vessel disease group （n=38）， double vessel disease group （n=26） and three vessel disease group （n=21） according to the coronary artery disease. The levels of serum soluble gp130， IL-6R and IL-6 were compared among three groups and their correlation with myocardial necrosis in patients with STEMI was analyzed. The patients who died during hospitalization and 3-year follow-up were divided into death group （n=11） and survival group （n=74）， the indexes of two groups were compared， and the predictive value of soluble gp130， IL-6R and IL-6 levels in prognosis of patients with STEMI was analyzed. Result： The levels of serum soluble gp130， IL-6R and IL-6 were significantly different among three groups （P<0.05）， and the levels of soluble gp130， IL-6R and IL-6 in three vessel disease group were higher than those in double vessel disease group and single vessel disease group. Spearman correlation analysis showed that serum soluble gp130， IL-6R and IL-6 levels were positively correlated with myocardial necrosis in patients with STEMI （P<0.05）. there was no significant difference in gender between survival group and death group （P>0.05）; there were significant differences in age， admission heart rate， gp130， IL-6R and IL-6 levels between survival group and death group （P<0.05）; logistic regression analysis showed that gp130， IL-6R and IL-6 were prognostic factors of patients with STEMI （P<0.05）. Conclusion： Myocardial necrosis in patients with STEMI is closely related to the levels of gp130 and IL-6R， and may have predictive value for the prognosis of patients with STEMI.

[Key words] gp130 IL-6R ST-segment elevation myocardial infarction Myocardial necrosis

First-author’s address： Shenhe District Second People’s Hospital， Shenyang 110043， China

doi：10.3969/j.issn.1674-4985.2021.28.033

动脉粥样硬化（AS）为人类动脉系统中的一种常见疾病，患病者会导致脑血管、心血管等重要部位栓塞，从而引发严重后果。急性心肌梗死（AMI）是冠心病严重疾病类型，患者在早期会出现胸闷、胸痛、紧缩感或压榨感，并伴有出汗和放射性疼痛等心肌坏死症状，持续时间达10 min以上一般考虑为急性心肌梗死[1-2]。……