宋剑锋　白明辉

【摘要】 目的：探討血管内皮生长因子相关性趋化因子-1（VCC-1）在胰腺癌组织中的表达及意义。方法：应用免疫组织化学方法测定VCC-1在52例胰腺癌及52例对应癌旁正常胰腺组织中的表达情况，并分析VCC-1和胰腺癌临床相关指标之间的关系。结果：VCC-1蛋白在胰腺癌组织中阳性表达率为76.92%高于癌旁组织的28.85%，差异有统计学意义（P<0.05）。VCC-1在Ⅰ、Ⅱ期胰腺癌组织的阳性表达率为69.23%（27/39）低于Ⅲ期的100%（13/13），差异有统计学意义（P<0.05）。VCC-1在有淋巴结转移的阳性表达率为91.67%（22/24）高于无淋巴结转移的64.29%（18/28），差异有统计学意义（P<0.05）。VCC-1在肿瘤直径≤2 cm中的阳性表达率为60.71%（17/28），低于肿瘤直径>2 cm的95.83%（23/24），差异有统计学意义（P<0.05）。VCC-1在低分化癌中的阳性表达率为83.33%（10/12），在中分化癌中的阳性表达率为87.88%（29/33），在高分化中的阳性表达率为14.29%（1/7），差异有统计学意义（P<0.05）。VCC-1与患者的年龄、性别及肿瘤部位无关（P>0.05）。VCC-1阴性表达组PC患者的中位生存期为26.9个月长于阳性表达组的16.3个月，差异有统计学意义（P<0.05）。结论：VCC-1在胰腺癌组织中呈高表达，VCC-1的表达可能在胰腺癌的发生、发展中起重要作用。

【关键词】 胰腺肿瘤 血管内皮生长因子相关性趋化因子-1 肿瘤标记

Expression and Significance of VCC-1 in Pancreatic Cancer Tissue/SONG Jianfeng， BAI Minghui. //Medical Innovation of China， 2021， 18（23）： -163

[Abstract] Objective： To investigate the expression and significance of VCC-1 in pancreatic cancer tissue. Method： The VCC-1 expressions in 52 specimens of pancreatic cancer tissues and 52 specimens of their adjacent normal pancreatic tissues were determined by immunohistochemical staining， and the relationship between VCC-1 and clinical indicators of pancreatic cancer were analyzed. Result： The positive expression rate of VCC-1

protein in pancreatic cancer tissues was 76.92%， higher than 28.85% in paracancer tissues， the difference was statistically significant （P<0.05）. The positive expression rate of VCC-1 in stage Ⅰ， Ⅱ pancreatic cancer tissues was 69.23% （27/39）， which was lower than 100% （13/13） in stage Ⅲ， the difference was statistically significant （P<0.05）. The positive expression rate of VCC-1 with lymph node metastasis was 91.67% （22/24）， which was higher than 64.29% （18/28） without lymph node metastasis， the difference was statistically significant （P<0.05）. The positive expression rate of VCC-1 in tumor diameter ≤2 cm was 60.71% （17/28）， which was lower than 95.83% （23/24） in tumor diameter >2 cm， the difference was statistically significant （P<0.05）. The positive expression rate of VCC-1 in low differentiation carcinoma was 83.33% （10/12）， the positive expression rate of VCC-1 in medium differentiation carcinoma was 87.88% （29/33）， and the positive expression rate of VCC-1 in high differentiation carcinoma was 14.29% （1/7）， the difference was statistically significant （P<0.05）. VCC-1 was not associated with age， gender or tumor site （P>0.05）. The median survival time of PC patients in VCC-1 negative expression group was 26.9 months， which was longer than 16.3 months in positive expression group， the difference was statistically significant （P<0.05）. Conclusion： The VCC-1 expression is increased in pancreatic cancer and its expression may be closely connected to the occurrence and development of pancreatic cancer.

[Key words] Pancreatic neoplasms VEGF correlated chemokine-1 Tumor markers

First-author’s address： Foresea Life Insurance Guangzhou General Hospital， Guangzhou 511300， China

doi：10.3969/j.issn.1674-4985.2021.23.039

胰腺癌（pancreatic cancer，PC）早期症状不明显，且发展快，预后差，其5年生存率为8%，有淋巴结转移者5年生存率为3%[1-8]。目前PC被诊断时多为中晚期，手术切除是最有效的治疗方法，但复发率比较高[9-13]。而导致PC发生和进展是多种基因及因素共同作用的结果[14]。已经有研究表明血管内皮生长因子相关性趋化因子-1（vsacular endothelial growth factor correlated chemokine 1，VCC-1）與乳腺癌、直肠癌及肝细胞癌的发生、发展有关[15]。笔者通过试验研究VCC-1在PC中的表达及意义，现报道如下。……