张沁铭　毛竹　霍玉廷　刘云亮

【摘要】 目的：探究與分析鼓室内注射氨溴索联合地塞米松在分泌性中耳炎中的效果及对分泌物炎症因子表达的影响。方法：选取2018年6月-2020年12月收治的80例分泌性中耳炎患者为研究对象，将其随机分为对照组（采用鼓室内注射地塞米松治疗）和观察组（采用鼓室内注射氨溴索联合地塞米松治疗），每组40例。比较两组的治疗效果和治疗前后的鼓室压力、语频区气导听阈、症状体征积分及分泌物炎症因子（IL-6、IL-8、TNF-α）水平。结果：观察组的总有效率显著高于对照组，差异有统计学意义（P<0.05）。治疗前，两组的鼓室压力、语频区气导听阈、症状体征积分及分泌物炎症因子比较，差异均无统计学意义（P>0.05）;治疗后7、14 d，观察组的鼓室压力、语频区气导听阈、症状体征积分及分泌物炎症因子均显著优于对照组，差异均有统计学意义（P<0.05）。结论：鼓室内注射氨溴索联合地塞米松在分泌性中耳炎中的临床效果较好，可显著改善分泌物炎症因子的表达，因此在分泌性中耳炎中的应用价值相对较高。

【关键词】 鼓室内注射 氨溴索 地塞米松 分泌性中耳炎 分泌物 炎症因子

Study on the Effect of Ambroxol Combined with Dexamethasone by Intratympanic Injection in the Patients with Secretory Otitis Media and Influence for Expression of Secretion Inflammatory Factors/ZHANG Qinming， MAO Zhu， HUO Yuting， LIU Yunliang. //Medical Innovation of China， 2021， 18（23）： 035-039

[Abstract] Objective： To investigate and analyze the effect of Ambroxol combined with Dexamethasone by intratympanic injection in the patients with secretory otitis media and influence for expression of secretion inflammatory factors. Method： A total of 80 patients with secretory otitis media from June 2018 to December 2020 were chosen as the research objects， they were randomly divided into control group （Dexamethasone by intratympanic injection） and observation group （Ambroxol combined with Dexamethasone by intratympanic injection）， 40 cases in each group. The treatment effect， tympanic pressure， air conduction threshold of speech frequency， symptom and sign scores， secretion inflammatory factors （IL-6， IL-8， TNF-α） before and after the treatment of two groups were compared. Result： The total effective rates of observation group was significantly higher than that of control group， there was statistically significant difference （P<0.05）. The tympanic pressure， air conduction threshold of speech frequency， symptom and sign scores， secretion inflammatory factors of two groups before the treatment were compared， there were no statistically significant differences （P>0.05）; 7 and 14 d after treatment， the tympanic pressure， air conduction threshold of speech frequency， symptom and sign scores， secretion inflammatory factors of observation group were all significantly better than those of control group， there were statistically significant differences （P<0.05）. Conclusion： The clinical effect of Ambroxol combined with Dexamethasone by intratympanic injection in the patients with secretory otitis media is better， and its influence for expression of secretion inflammatory factors are significantly improved， so its application value in the patients with secretory otitis media is relatively higher.

[Key words] Intratympanic injection Ambroxol Dexamethasone Secretory otitis media Secretion Inflammatory factors

First-author’s address： Fujian Provincial Maternity and Children’s Hospital， Fuzhou 350000， China

doi：10.3969/j.issn.1674-4985.2021.23.009

分泌性中耳炎的臨床发病率较高，其可导致患者出现耳鸣、耳痛、耳闷及听力下降等多种症状体征，严重影响患者的日常生活及生存质量。临床中与分泌性中耳炎相关的研究显示，患者除表现出上述症状体征外，耳部局部分泌物炎症因子的表达也相对异常，且随着疾病的控制，其表达水平随之得到控制[1-2]，因此对分泌性中耳炎患者进行治疗的过程中，上述方面的评估价值均较高。……